Brain Volume Reduction after Whole-Brain Radiotherapy: Quantification and Prognostic Relevance

Abstract

Background

Recent studies have questioned the value of adding whole-brain radiotherapy (WBRT) to stereotactic radiosurgery (SRS) for brain metastasis treatment. Neurotoxicity, including radiation-induced brain volume reduction, could be one reason why not all patients benefit from the addition of WBRT. In this study, we quantified brain volume reduction after WBRT and assessed its prognostic significance.

Methods

Brain volumes of 91 patients with cerebral metastases were measured during a 150-day period after commencing WBRT, and were compared to their pretreatment volumes. The average daily relative change in brain volume of each patient, referred to as the 'brain volume reduction rate', was calculated. Univariate and multivariate Cox regression analyses were performed to assess the prognostic significance of the brain volume reduction rate, as well as of three treatment-related and nine pretreatment factors. A one-way analysis of variance was used to compare the brain volume reduction rate across recursive partitioning analysis (RPA) classes.

Results

On multivariate Cox regression analysis, the brain volume reduction rate was a significant predictor of overall survival after WBRT (P<.001), as well as the number of brain metastases (P=.002) and age (P=.008). Patients with a relatively favorable prognosis (RPA classes 1 and 2) experienced significantly less brain volume decrease after WBRT than patients with a poor prognosis (RPA class 3) (P=.001). There was no significant correlation between delivered radiation dose and brain volume reduction rate (P=.147).

Conclusion

In this retrospective study, a smaller decrease in brain volume after WBRT was an independent predictor of longer overall survival.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2hEguQl