Publication date: Available online 18 August 2017
Source:Clinical Neurology and Neurosurgery
Author(s): Pavlos Texakalidis, Kimon Bekelis, Elias Atallah, Stavropoula Tjoumakaris, Robert H. Rosenwasser, Pascal Jabbour
Flow diversion with the Pipeline Embolization Device (PED) is reported as a safe and efficient treatment for patients with intracranial aneurysms; however, literature discussing the antiplatelet (APT) regimen used before and after the PED is limited. Our aim was to systematically review and summarize available data regarding the APT regimen and the platelet function test (PFT) that was used. We also sought to provide an overview of the aneurysm morphologies and adverse event rates associated with the PED use. This systematic review was conducted according to the PRISMA statement and eligible studies were identified through search of the PubMed and Cochrane databases. We reviewed 28 studies, involving 1,556 patients that underwent aneurysm treatment with the PED. The preprocedural aspirin (ASA) 300- 325mg (2-14 days) combined with clopidogrel 75mg (3 to >10 days) were used as a treatment strategy in 61.7% of patients and ASA 81mg with clopidogrel 75mg for 5–10days for 27%. Patients who received low versus high dose pre-PED ASA, were at less risk for a hemorrhagic event (0.7% versus 3.3%, p=0.053); however no statistical significance was reached. There was also lack of relationship between patients that received low versus high preprocedural ASA in terms of thromboembolic events. Regarding postprocedural APT, ASA (>6months) and clopidogrel (3- 12 months) was the regimen of choice for 93% of patients. Most studies conducted at least one PFT, most common being the VerifyNow. The most frequently reported target P2Y12 Reaction unit (PRU) and Aspirin Reaction Unit (ARU) values were <230 and <550 respectively. There was no statistically demonstrable difference in regards to thrombotic events between centers that conducted at least one PFT and centers that did not test their patients with a PFT. The overall rates of symptomatic thrombotic episodes were 6.6% and hemorrhagic were 3%. The pre- and post-PED APT dose and duration varies across different institutions. More prospective studies are needed to compare the efficacy of different APT agents and reach conclusions regarding use of PFT and platelet reaction values in order to decrease hemorrhagic and thromboembolic complications associated with the PED.
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2wfM7pT
Αρχειοθήκη ιστολογίου
-
►
2023
(269)
- ► Φεβρουαρίου (133)
- ► Ιανουαρίου (136)
-
►
2022
(2046)
- ► Δεκεμβρίου (165)
- ► Σεπτεμβρίου (161)
- ► Φεβρουαρίου (165)
-
►
2021
(3028)
- ► Δεκεμβρίου (135)
- ► Σεπτεμβρίου (182)
- ► Φεβρουαρίου (324)
-
►
2020
(1051)
- ► Δεκεμβρίου (292)
- ► Σεπτεμβρίου (60)
- ► Φεβρουαρίου (28)
-
►
2019
(2277)
- ► Δεκεμβρίου (18)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (89)
-
►
2018
(26280)
- ► Δεκεμβρίου (189)
- ► Φεβρουαρίου (6130)
- ► Ιανουαρίου (7050)
-
▼
2017
(33948)
- ► Δεκεμβρίου (6715)
- ► Σεπτεμβρίου (6470)
-
▼
Αυγούστου
(6833)
-
▼
Αυγ 18
(324)
- Exploring Planting and Filter Media in Stormwater ...
- The dual role of group V secretory phospholipase A...
- Lack of association between interleukin 28B polymo...
- The dual role of group V secretory phospholipase A...
- Comparison of Combined Spike Detection and Cluster...
- Home-cage anxiety levels in a transgenic rat model...
- Reproducibility of task activation using the Adden...
- Microdialysis and its use in behavioural studies: ...
- Method of derivation and differentiation of mouse ...
- Hypofractionated stereotactic radiotherapy to the ...
- Impact of surgery, adjuvant therapy and other prog...
- Physiologic Considerations in Trauma Patients Unde...
- A Graphical Guide to the REBOA: Five Life-Saving S...
- Resuscitative Endovascular Balloon Occlusion of th...
- Human neural stem cell transplantation into the co...
- Increased serum levels of fetuin B in patients wit...
- Increased serum levels of fetuin B in patients wit...
- Phonak to Introduce Hearing Aid That Connects to A...
- Development of the gut microbiota in infancy and i...
- Telmesani Radiological Classification of the Locat...
- Ablation of facial adenoma sebaceum using the Vers...
- Treatment of Swedish Patients with Graves' Hyperth...
- Protection against TBI-Induced Neuronal Death with...
- Impaired Baroreflex Function during Orthostatic Ch...
- A Season of American Football Is Not Associated wi...
- Systemic Administration of Exosomes Released from ...
- Transcriptional Changes in the Mouse Retina after ...
- Protection against TBI-Induced Neuronal Death with...
- Impaired Baroreflex Function during Orthostatic Ch...
- A Season of American Football Is Not Associated wi...
- Systemic Administration of Exosomes Released from ...
- Transcriptional Changes in the Mouse Retina after ...
- Ablation of facial adenoma sebaceum using the Vers...
- Analysis of temperature increase in swine gingiva ...
- Primary intraosseous squamous cell carcinoma - A r...
- Ultrastructural changes in cell death
- A rare coexistence of aspergillosis with actinomyc...
- Use of jaggery and honey as adjunctive cytological...
- Trends in oral squamous cell carcinoma: Diagnosis ...
- The so-called “combined epithelial odontogenic tum...
- Small cell neuroendocrine carcinoma of the paranas...
- Influence of legislations and news on Indian inter...
- Cytological spectrum of salivary gland lesions and...
- Evaluation of paxillin expression in patients with...
- Validation of immunoexpression of tenascin-C in or...
- Darier disease: A rare genodermatosis
- Immunohistochemical analysis of stromal fibrocytes...
- From the Editor's Desk
- Hemangiolymphangioma of buccal mucosa: A rare case...
- Optoacoustic detection of early therapy-induced tu...
- p53 non-genotoxic activation and mTORC1 inhibition...
- Defective cyclin B1 induction in trastuzumab-emtan...
- Dasatinib reversibly disrupts endothelial vascular...
- Selected alkylating agents can overcome drug toler...
- Reply: Discussion on "Intraoperative comparison of...
- Role of Mitomycin C in Preventing Capsular Contrac...
- Reply: Medial Row Perforators Are Associated with ...
- Comments on "Should Immediate Autologous Breast Re...
- Why Women Request Labiaplasty.
- Reply: Blood Congestion Can be Rescued by Hemodilu...
- Reply: The Impact of Two Operating Surgeons on Mic...
- Comment on: Application of Posterior Thigh Three-D...
- The Impact of Two Operating Surgeons on Microsurgi...
- Response to Letter by Dr. Ciancio to PRS manuscrip...
- "Medial Row Perforators Are Associated with Higher...
- Reply to Letter to the Editor: Why Women Request L...
- response letter for "Simplifying the Forehead Flap...
- Telmesani Radiological Classification of the Locat...
- Second-Order Peer Reviews of Clinically Relevant A...
- Grip Strength on the Unaffected Side as an Indepen...
- Feasibility of Restoring Walking in Multiple Scler...
- Isometric Exercise for the Cervical Extensors Can ...
- The State of Disability Awareness in American Medi...
- Efficacy of Radial Extracorporeal Shock Wave Thera...
- Authors' Response to Letter to the Editor “Ultraso...
- Can Early Rehabilitation on the General Ward After...
- The Magnitude and Time Course of Muscle Cross-sect...
- Massage Therapy for Pain and Function in Patients ...
- Responsiveness of Myofascial Trigger Points to Sin...
- Strengthening Rehabilitation in Health Systems Wor...
- Prospective Evaluation of Postural Control and Gai...
- Ultrasound-Guided C7 Cervical Medial Branch Block ...
- A Rarely Seen Complication That Causes Increase in...
- Another Etiology of Meralgia Paresthetica-Impingem...
- Radiopaque Line in Front of the Lumbar Spine Durin...
- Lessons learnt from incidents involving the airway...
- Hypo-fractionated SBRT for localized prostate canc...
- Colorectal cancer patient’s self-efficacy for mana...
- Organic Matter and Nutrients Removal in Tropical C...
- Performance Analysis of Photolytic, Photocatalytic...
- Tumori della ghiandola parotide
- Linfangiomi cervicofacciali: imaging, diagnosi e t...
- Epistassi
- Stimulus Characteristics of Single-Word Tests of C...
- Comparative analysis of the effects of CO 2 fracti...
- The 3D Printing of the Paralyzed Vocal Fold: Added...
- A Review of the Physiological Effects and Mechanis...
- The Effect of Vocal Fold Inferior Surface Hypertro...
- Risk Factors for Voice Disorders in University Pro...
- Into the Lead: How EJVES Became the Leading Journa...
-
▼
Αυγ 18
(324)
-
►
2016
(4179)
- ► Σεπτεμβρίου (638)
- ► Φεβρουαρίου (526)
- ► Ιανουαρίου (517)
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου