Long-term therapy with intravenous zoledronate increases the number of nonattached osteoclasts

Bisphosphonates (BPs) are antiresorptive drugs that are being used clinically to treat bone-related diseases, such as osteoporosis or cancer with bone metastasis (Williams et al., 2014). Users of these drugs are known to be at higher risk of developing osteonecrosis of the jaw (ONJ), which was first described by Marx (2003).

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