AbstractPurpose.Few population studies have examined patterns of systemic therapy administration in metastatic pancreatic cancer (MPC) or the predictors associated with specific treatment choices.Patients and Methods.We assessed 4,011 consecutive MPC patients who received chemotherapy between January 2005 and December 2015 at academic, private, and community‐based oncology practices subscribing to a U.S.‐wide chemotherapy order entry system capturing disease, patient, provider, and treatment data. Multivariate analyses of these prospectively recorded characteristics identified significant predictors of specific therapeutic choices.Results.Overall, 100 different regimens were used in first‐line treatment of MPC. First‐line gemcitabine monotherapy usage fell steadily from 72% in 2006 to 16% in 2015. This steep decline mirrored increases in first‐line usage of both 5 fluorouracil, leucovorin, irinotecan and oxaliplatin (FOLFIRINOX) and gemcitabine + nab‐paclitaxel. Younger male patients were more likely to receive FOLFIRINOX as first‐line treatment, whereas patients treated at community practices and by oncologists with lower MPC patient volume were more likely to receive gemcitabine plus nab‐paclitaxel (all p ≤ .05). Among all patients receiving first‐line chemotherapy for MPC, 49% went on to receive second‐line therapy and 19% received third‐line therapy; administration of second‐ and third‐line therapies increased steadily over the time course of follow‐up. Younger patients and those treated by oncologists with higher MPC patient volume were more likely to receive second‐ and third‐line therapies.Conclusion.This population‐based study provides insight into treatment patterns of MPC in the U.S. Usage patterns varied greatly according to patient and provider characteristics.Implications for Practice.This study examined real world metastatic pancreatic cancer treatment patterns in the United States with the goals of understanding changes in chemotherapy treatment frequencies over time and determining the individual predictors that underlie the chemotherapy choices oncologists make for their patients. Our data set is unique in that it captured not only patient‐level data, but also oncologist‐level data. It also captured data from private and community practices as well as academic centers. To our knowledge, this is the only data set that can give this degree of insight into oncologist decision making practices.
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2wBqs8F
Αρχειοθήκη ιστολογίου
-
►
2023
(269)
- ► Φεβρουαρίου (133)
- ► Ιανουαρίου (136)
-
►
2022
(2046)
- ► Δεκεμβρίου (165)
- ► Σεπτεμβρίου (161)
- ► Φεβρουαρίου (165)
-
►
2021
(3028)
- ► Δεκεμβρίου (135)
- ► Σεπτεμβρίου (182)
- ► Φεβρουαρίου (324)
-
►
2020
(1051)
- ► Δεκεμβρίου (292)
- ► Σεπτεμβρίου (60)
- ► Φεβρουαρίου (28)
-
►
2019
(2277)
- ► Δεκεμβρίου (18)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (89)
-
►
2018
(26280)
- ► Δεκεμβρίου (189)
- ► Φεβρουαρίου (6130)
- ► Ιανουαρίου (7050)
-
▼
2017
(33948)
- ► Δεκεμβρίου (6715)
- ► Σεπτεμβρίου (6470)
-
▼
Αυγούστου
(6833)
-
▼
Αυγ 11
(280)
- Cognitive functioning in children with self-limite...
- Laparoscopic reversal of mini-gastric bypass to or...
- Surgical approaches to adenocarcinoma of the gastr...
- Childhood body mass index and height in relation t...
- Activity Demands During Multi-Directional Team Spo...
- Traditional Chinese medicine as adjunctive therapy...
- Childhood body mass index and height in relation t...
- Accelerated Long-Term Forgetting Is Not Epilepsy S...
- Mediating burden and stress over time: Caregivers ...
- Mineralization-defects are comparable in fluorotic...
- Cervical mass as the first clinical manifestation ...
- Does CT help in predicting preepiglottic space inv...
- Correlation of soft palate length with velum obstr...
- Clinical course of incidental parathyroidectomy: S...
- Disruption of frontal-parietal connectivity during...
- Accelerated Long-Term Forgetting Is Not Epilepsy S...
- In Response.
- In Response: Concerns With Rate of Rise of Carbon ...
- The Subtleties of Language as a Reason for Failure...
- Core Temperature Monitoring in Obstetric Spinal An...
- Reducing Mortality in Acute Kidney Injury.
- Necrotic mucosal CD30-positive ulcer on the oral m...
- Postoperative complications after head and neck op...
- Hearing Health USA and Belsono Partner to Remove S...
- Validation study of accelerometer in measuring som...
- Validation study of accelerometer in measuring som...
- A Limited Submuscular Direct-to-Implant Technique ...
- The Supra-Inframammary Fold Approach to Breast Aug...
- Palliative external beam radiotherapy for the trea...
- Beliefs and perceptions that impair cleft care tre...
- Pathologic anatomy of the soft palate, part 2: The...
- Tongue harmatoma in association with cleft palate:...
- Impact of educational and socioeconomic status of ...
- Morbidity associated with anterior iliac crest har...
- Effect of palatoplasty on hearing ability of nonsy...
- Newer training tool in cleft lip and palate surgery
- Velopharyngeal dysfunction of neurogenic origin: E...
- Autologous alveolar bone graft integration based o...
- Studying the impact of cleft of lip and palate amo...
- Prosthodontic rehabilitation of velopharyngeal ins...
- Effectiveness of a training program for community-...
- Developing a new scissor for cleft surgery: The cl...
- Technique of Laparoscopic Hysterectomy and Pelvic ...
- Breast Cancer Immunotherapy: Facts and Hopes
- Simultaneous targeting of two distinct epitopes on...
- The combination of metformin and valproic acid ind...
- TDP1 is critical for the repair of DNA breaks indu...
- Exploiting radiation-induced signaling to increase...
- MicroRNA-720 regulates E-cadherin-{alpha}E-catenin...
- A Systematic Review of Patient-Reported Outcomes f...
- Recognition and Management of Acute Dacryocystic R...
- Clinical Outcomes in Children With Orbital Celluli...
- Safety Comparison of Laryngeal Mask Use With Endot...
- ESPGHAN Distinguished Service Award 2017 to Profes...
- Successful Use of Sirolimus in Children With Large...
- Response to Letter to the Editor: Bile Acid Replac...
- Letter regarding “Effect of laser on pain relief a...
- Redirect Health Offers Affordable Healthcare Alter...
- Hyaluronan-mediated mononuclear leukocyte binding ...
- Anticancer drugs and the regulation of Hedgehog ge...
- Hyaluronan-mediated mononuclear leukocyte binding ...
- Current concepts in bone metastasis, contemporary ...
- Randomized controlled trial of EndoWrist-enabled r...
- Advances in closed-loop deep brain stimulation dev...
- Dermoid Cyst of the Prepontine Cistern and Meckel'...
- Focal Increased Tc-99m MDP Uptake in the Nutrient ...
- How do red and infrared low-level lasers affect fo...
- Dysphagia and Speech-Language Pathology Involvemen...
- First US Transgender Surgery, Psychiatry Fellowships
- Opioid Prescribing Behavior After Elective Surgery...
- Optimaler Resektionsrand für die brusterhaltende O...
- Feasibility and diagnostic accuracy of point-of-ca...
- Erosión ósea del canal carotídeo. Síndrome de Grad...
- Evaluación de la capacidad formativa del libro del...
- Arteria lusoria: A rare cause of tracheal compression
- Seudotumor inflamatorio subglótico en un niño de 3...
- Primary tuberculosis of the nasal septum: The non-...
- Neurocognitive sparing of desktop microbeam irradi...
- New study reports benefits of dental therapists’ care
- Prospective Evaluation of the Relationship Between...
- Robert L. Comis: In Memoriam
- Curative, Life‐Extending, and Palliative Chemother...
- Data Linkage to Improve Geriatric Oncology Researc...
- Prolonged Pemetrexed Infusion Plus Gemcitabine in ...
- Health Care Resource Utilization and Associated Co...
- A Phase II Multi‐Center Study of Bevacizumab in Co...
- Hepatosplenic Candidiasis Without Prior Documented...
- Association Study Confirmed Three Breast Cancer‐Sp...
- The Best Thing I Saw at ASCO
- Male Breast Cancer as a Second Primary Cancer: Inc...
- Debunking the Delusion That Precision Oncology Is ...
- First‐Line Palliative HER2‐Targeted Therapy in HER...
- Impact of Age on Outcomes with Immunotherapy for P...
- The National Cancer Institute Community Cancer Cen...
- Efficacy of Trabectedin in Patients with Advanced ...
- Social Network Structures of Breast Cancer Patient...
- Implementation of the Edmonton Symptom Assessment ...
- Patterns of Chemotherapy Use in a U.S.‐Based Cohor...
- What's the Harm?
- Prognostic Value of Pre- and Post-Treatment FDG PE...
-
▼
Αυγ 11
(280)
-
►
2016
(4179)
- ► Σεπτεμβρίου (638)
- ► Φεβρουαρίου (526)
- ► Ιανουαρίου (517)
Παρασκευή 11 Αυγούστου 2017
Patterns of Chemotherapy Use in a U.S.‐Based Cohort of Patients with Metastatic Pancreatic Cancer
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου