Predictive Factors of Unfavorable Events After Gamma Knife Radiosurgery for Vestibular Schwannoma.

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Predictive Factors of Unfavorable Events After Gamma Knife Radiosurgery for Vestibular Schwannoma.

World Neurosurg. 2017 Aug 04;:

Authors: Kim JH, Jung HH, Chang JH, Chang JW, Park YG, Chang WS

Abstract
OBJECTIVE: Gamma knife radiosurgery (GKS) for the treatment of vestibular schwannoma (VS) introduces risks to the facial nerve and auditory perception, and may involve post-treatment complications such as pseudoprogression, hydrocephalus, and other cranial neuropathies. This study of patients with VS who underwent GKS investigated radiosurgical results, focusing on post-treatment complications and identifying the factors that predict such complications.
METHODS: We undertook a retrospective review of all VS patients treated with the Perfexion Leksell gamma knife between November 2007 and October 2010 at our institution. Patients who underwent at least 12 months of clinical and radiological assessments before and after GKS were included.
RESULTS: All 235 patients were included in the analyses reported here. The 5-year serviceable hearing and facial nerve preservation values were 73.9% and 94.3%, respectively. Following GKS, 43 patients (18.30%) showed pseudoprogression, 15 (6.38%) exhibited hydrocephalus, 22 (9.36%) showed trigeminal neuropathy, 14 (5.96%) showed vertigo, and 25 (10.64%) showed facial myokymia. According to multivariate analysis, solid tumor nature was significantly associated with pseudoprogression and patient age was significantly associated with hydrocephalus. Patients receiving margin dose ≥ 13 Gy had a significantly higher probability of loss of serviceable hearing. Patients with smaller tumors had a trigeminal nerve preservation rate comparable to patients harboring larger tumors. Patients receiving margin dose < 13 Gy or older patients had a significantly higher probability of vestibular nerve dysfunction.
CONCLUSIONS: Further prospective studies should be designed to provide further insight into the exact relationship between the predictive factors we investigated and post-treatment complications.

PMID: 28826715 [PubMed - as supplied by publisher]

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