Hearing crosstalk: the molecular conversation orchestrating inner ear dorsoventral patterning.

Hearing crosstalk: the molecular conversation orchestrating inner ear dorsoventral patterning.

Wiley Interdiscip Rev Dev Biol. 2017 Oct 11;:

Authors: Ohta S, Schoenwolf GC

Abstract
The inner ear is a structurally and functionally complex organ that functions in balance and hearing. It originates during neurulation as a localized thickened region of rostral ectoderm termed the otic placode, which lies adjacent to the developing caudal hindbrain. Shortly after the otic placode forms, it invaginates to delineate the otic cup, which quickly pinches off of the surface ectoderm to form a hollow spherical vesicle called the otocyst; the latter gives rise dorsally to inner ear vestibular components and ventrally to its auditory component. Morphogenesis of the otocyst is regulated by secreted proteins, such as WNTs, BMPs, and SHH, which determine its dorsoventral polarity to define vestibular and cochlear structures and sensory and nonsensory cell fates. In this review, we focus on the crosstalk that occurs among three families of secreted molecules to progressively polarize and pattern the developing otocyst. For further resources related to this article, please visit the WIREs website.

PMID: 29024472 [PubMed - as supplied by publisher]

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