Long term correlation of subthalamic beta band activity with motor impairment in patients with Parkinson’s disease

Publication date: November 2017
Source:Clinical Neurophysiology, Volume 128, Issue 11
Author(s): Wolf-Julian Neumann, Franziska Staub-Bartelt, Andreas Horn, Julia Schanda, Gerd-Helge Schneider, Peter Brown, Andrea A. Kühn
ObjectivesTo investigate the long term association of subthalamic beta activity with parkinsonian motor signs.MethodsWe recruited 15 patients with Parkinson's disease undergoing subthalamic DBS for local field potential recordings after electrode implantation, and at 3 and 8months post-operatively using the implantable sensing enabled Activa PC+S (Medtronic). Three patients dropped out leaving 12 patients. Recordings were conducted ON and OFF levodopa at rest. Beta (13–35Hz) peak amplitudes were extracted, compared across time points and correlated with UPDRS-III hemibody scores.ResultsPeaks in the beta frequency band (13–35Hz) in the OFF medication state were found in all hemispheres. Mean beta activity was significantly suppressed by levodopa at all recorded time points (P<0.007) and individual beta power amplitude correlated with parkinsonian motor impairment across time points and dopaminergic states (pooled data; ρ=0.25, P<0.001).ConclusionsOur results indicate that beta-activity is correlated with parkinsonian motor signs over a time period of 8months.SignificanceBeta-activity may be a chronically detectable biomarker of symptom severity in PD that should be further evaluated under ongoing DBS.



from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2yi3TqS