Nodal factors predictive of recurrence and survival in patients with oral cavity squamous cell carcinoma

Abstract

Objectives

Lymph node (LN) metastasis of oral cavity squamous cell carcinoma (OSCC) is associated with survival outcomes. However, the relationship between different metastatic nodal factors and treatment outcomes require further elucidation. This study examined nodal factors predictive of recurrence and survival in patients with OSCC.

Methods

This prospective observational study included 157 patients with OSCC who underwent surgery between 2010 and 2015. Clinicopathological and follow-up information were recorded. Univariate and multivariate Cox proportional hazard models were performed to identify factors associated with recurrence-free survival, disease-specific survival and overall survival.

Results

Sixty-five of 157 patients (41.4%) had neck metastasis. During a median follow-up of 46 months, any recurrences and all deaths occurred in 43 (27.4%) and 43 (27.4%) of cases, respectively. All nodal factors (LN classification, size, number and ratio) and extra-nodal extension were significantly associated with all survival outcomes (P <0.001). Multivariate analyses indicated that a tumour size >2 cm and LN ratio were independentlyassociated with all survival (P <0.05). Patients with LN ratio >0.05 had six-fold higher recurrence and mortality rates than other patients (P <0.001).

Conclusion

LN ratio is an independent and predictive determinant of post-treatment recurrence and survival.

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from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2fRZVQS