Αρχειοθήκη ιστολογίου

Τετάρτη 11 Οκτωβρίου 2017

Oncological safety of nipple-sparing prophylactic mastectomy: A review of the literature on 3716 cases

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Publication date: Available online 10 October 2017
Source:Annales de Chirurgie Plastique Esthétique
Author(s): T. Muller, A. Baratte, C. Bruant-Rodier, F. Bodin, C. Mathelin
IntroductionThe objective of our study was to evaluate the risk of cancer after prophylactic nipple-sparing mastectomy (PNSM).Material and methodsThe PubMed database was consulted using the following key-words: "nipple-sparing mastectomy", "prophylactic", "locoregional recurrence", "oncological risk". Articles published between January 1995 and December 2016 were searched.ResultsOut of the 270 articles found, 19 were included. Overall, 15 studies were retrospective, 2 prospective, 2 prospective and retrospective and 3 were multicentric. All told, they involved 3890 patients corresponding to 6786 mastectomies, among which the total number of prophylactic nipple-sparing mastectomies was 3716. Average age of the patients was 44.4years and average follow-up was 38.4months (8–168months); 29.4% of them had a BRCA 1 or 2 mutation; 85 and 15% underwent prosthetic and autologous reconstructions, respectively. Average cancer rates exterior to and within the nipple areolar complex (NAC) were 0.2 and 0.004%, respectively. The overall average rate of histological pre-malignant lesions in the nipple areolar complex was 1.5%. The overall complication rate was 20.5%, and necrosis rates of the nipple areolar complex and the skin were 8.1 and 7.1%, respectively.ConclusionIn prophylactic breast surgery, conservation of the nipple areolar complex does not seem to increase the risk of cancer development. However, short follow-up time and the different methodologies applied in the different studies presently preclude generalization of the technique.



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