Pansclerotic morphea associated with hypohidrosis and anti-M3 muscarinic acetylcholine receptor antibodies

Abstract

A man in his 50s was referred to our hospital due to a 3-month history of extensive hypohidrosis that he first realized in his upper trunk. He subsequently noticed tenseness of the skin on the hypohidrotic areas. He had a medical history of hyperlipidemia, duodenum ulcer and obsessive-compulsive disorder, but had not received drugs known to induce sclerosis or hypohidrosis. Physical examination showed diffuse, shiny, mildly sclerotic skin with a symmetrical distribution in the upper extremities and the trunk; however, the hands, axillae and lateral chest were spared (Figure 1a).

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