Publication date: January 2018
Source:European Journal of Cancer, Volume 88
Author(s): Katrin Schaper-Gerhardt, Steven Okoye, Rudolf Herbst, Jens Ulrich, Patrick Terheyden, Claudia Pföhler, Jochen S. Utikal, Alexander Kreuter, Peter Mohr, Edgar Dippel, Imke Satzger, Antje Sucker, Dirk Schadendorf, Selma Ugurel, Ralf Gutzmer
BackgroundTargeted therapies with BRAF plus MEK inhibitors (BRAFi; MEKi) represent the major treatment strategy for patients with BRAF-mutated metastatic melanoma (MM). Previous analyses suggested a correlation between programmed death-ligand 1 (PD-L1) expression in tumour tissues and the outcome of targeted therapies. This study investigated PD-L1 as a potential predictive biomarker of BRAFi-based targeted therapies in MM patients.Patients and methodsWe analysed two independent cohorts of BRAF V600-mutated MM patients undergoing BRAFi-based therapies for PD-L1 expression in pre-treatment tumour tissues. The oligocentre cohort 1 included 83 patients whose tumour tissues were analysed retrospectively with the anti-PD-L1 antibody clone E1L3N. The multicentre cohort 2 included 58 patients whose tumour tissues were analysed prospectively within the framework of the "Registry of the Arbeitsgemeinschaft Dermatologische Onkologie" (ADOREG) and "Tissue Registry in Melanoma" (TRIM) project using the anti-PD-L1 antibody clone 28–8.ResultsPD-L1 expression in pre-treatment tumour tissue did not correlate with response or survival to BRAFi-based therapies in both MM patient cohorts. This finding was not influenced by retrospective versus prospective immunohistochemistry analyses, oligocentre versus multicentre cohorts or the different anti-PD-L1 antibody clones used. In cohort 1, PD-L1 positivity was detected in tumour tissue of 41.0% and 18.1% of patients (cut-off 1% and 5%, respectively). In cohort 2, 58.6% and 39.7% of patients showed PD-L1 positivity (cut-off 1% and 5%, respectively).ConclusionIn two independent cohorts including a total of 141 MM patients, PD-L1 expression in tumour tissue did not correlate with the outcome of BRAFi-based treatment. Therefore, PD-L1 cannot be recommended for the use as a predictive biomarker of BRAFi-based therapy in BRAF V600-mutated MM.
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2AcQnbr
Αρχειοθήκη ιστολογίου
-
►
2023
(269)
- ► Φεβρουαρίου (133)
- ► Ιανουαρίου (136)
-
►
2022
(2046)
- ► Δεκεμβρίου (165)
- ► Σεπτεμβρίου (161)
- ► Φεβρουαρίου (165)
-
►
2021
(3028)
- ► Δεκεμβρίου (135)
- ► Σεπτεμβρίου (182)
- ► Φεβρουαρίου (324)
-
►
2020
(1051)
- ► Δεκεμβρίου (292)
- ► Σεπτεμβρίου (60)
- ► Φεβρουαρίου (28)
-
►
2019
(2277)
- ► Δεκεμβρίου (18)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (89)
-
►
2018
(26280)
- ► Δεκεμβρίου (189)
- ► Φεβρουαρίου (6130)
- ► Ιανουαρίου (7050)
-
▼
2017
(33948)
- ► Δεκεμβρίου (6715)
-
▼
Νοεμβρίου
(6500)
-
▼
Νοε 28
(202)
- Online education improves pediatric residents’ und...
- Surgical treatment options following chemotherapy ...
- A case report of brown tumor in a patient with chr...
- Functional implications of novel ADAM10 mutations ...
- Induction of DNA double-strand breaks in human gin...
- Bisphenol A release from an orthodontic resin comp...
- Using glass-graded zirconia to increase delaminati...
- Effects of different sterilization methods on surf...
- Effect of tribochemical treatments and silane reac...
- The effect of chewing simulation on surface roughn...
- Dentin bonding systems: From dentin collagen struc...
- Effect of titania content and biomimetic coating o...
- Cross-linking effect on dentin bond strength and M...
- An interproximal model to determine the erosion-pr...
- Mechanism of bioactive molecular extraction from m...
- Hierarchical microcrack model for materials exempl...
- Light irradiance through novel CAD–CAM block mater...
- Free flap reconstruction for trauma in the early p...
- Silicone lip implant for augmentation in cleft lip
- Robotic nipple-sparing mastectomy with immediate r...
- Review of follow-up requirements of low-risk squam...
- Refining the cross-finger flap: considerations of ...
- Analysis of the Correlation between Deformational ...
- Long-term functional outcome in case series of tib...
- Short correspondence: reverse lymphatic mapping wi...
- Post-operative care of VRAM flaps for perineal rec...
- The use of a ‘pocket’ printer to improve documenta...
- Spreader graft placement: location, location, loca...
- Surgical-site infection following lymph node excis...
- Analysis of the correlation between deformational ...
- Bleeding on the cutting edge; a systematic review ...
- Immediate nipple reconstruction during skin-sparin...
- Outcome measurement in plastic surgery
- Aesthetic day surgery safety in a UK facility- a 4...
- Sentinel node biopsy in desmoplastic thin melanoma...
- A prospective, randomized-controlled pilot study c...
- Serial excision with power-stretching of the skin ...
- Injection Guide for Botulinum Toxin and Injectable...
- Image analysis of interarytenoid area to detect ca...
- Letter to the editor
- How to Write a Research Proposal in Vascular Surge...
- Pretreatment C-reactive protein/albumin ratio is a...
- An investigation of survivorship clinic attendance...
- Apigenin, by activating p53 and inhibiting STAT3, ...
- ALX4, an epigenetically down regulated tumor suppr...
- Drug repurposing for the treatment of glioblastoma...
- Site-specific selection reveals selective constrai...
- Comparison of atopy patch testing to skin prick te...
- TEM8/ANTXR1-specific CAR T cells as a targeted the...
- Gait performance and foot pressure distribution du...
- Post-operative care of VRAM flaps for perineal rec...
- Aging of the bony orbit is a major cause of age-re...
- A prospective, randomized-controlled pilot study c...
- Aesthetic day surgery safety in a UK facility- a 4...
- Updated anatomy of the buccal space and its implic...
- Immediate nipple reconstruction during skin-sparin...
- Surgical-site infection following lymph node excis...
- Serial excision with power-stretching of the skin ...
- Free flap reconstruction for trauma in the early p...
- Split-sciatic Nerve surgery: a new microsurgical m...
- Bleeding on the cutting edge; a systematic review ...
- Liposuction as an effective treatment for lower ex...
- Robotic nipple-sparing mastectomy with immediate r...
- Refining the cross-finger flap: considerations of ...
- Long-term functional outcome in case series of tib...
- Sentinel node biopsy in desmoplastic thin melanoma...
- The use of a ‘pocket’ printer to improve documenta...
- Short correspondence: reverse lymphatic mapping wi...
- Analysis of the correlation between deformational ...
- Letter to the editor
- Image analysis of interarytenoid area to detect ca...
- Prevalence and Progression Rate of Diabetic Retino...
- Relation of Carotid Artery Plaque to Coronary Hear...
- Monogenic Diabetes Not Caused By Mutations in Mody...
- Impact of robust treatment planning on single- and...
- Unconscious physiological response of healthy volu...
- Leaflets and continual educational offerings led t...
- Marriage and risk of dementia: systematic review a...
- Marriage and risk of dementia: systematic review a...
- Impact of tumour histology on survival in advanced...
- Variation in ‘fast-track’ referrals for suspected ...
- Citation for the 2016 Down Surgical Prize – Michae...
- ASPS/PSF Sponsored Symposia and Workshops
- The Impact of Two Operating Surgeons on Microsurgi...
- Acellular Dermal Matrix in Immediate Expander/Impl...
- Application of Posterior Thigh Three-Dimensional P...
- Clinical and Quantitative Isokinetic Comparison of...
- Primary Septal Cartilage Graft for the Unilateral ...
- Revisiting the Fundamental Operative Principles of...
- Discussion: Revisiting the Abdominal Donor Site In...
- Reply: Direct-to-Implant Breast Reconstruction wit...
- The Impact of Autologous Breast Reconstruction on ...
- Why Women Request Labiaplasty
- Evidence-Based Performance Measures: Quality Metri...
- Reply: Simplifying the Forehead Flap for Nasal Rec...
- Prospective Controlled Study of Chin Augmentation ...
- Trends and Predictors of National Institutes of He...
- Mentor Contour Profile Gel Implants: Clinical Outc...
- Orthognathic Surgery: Principles, Planning and Pra...
- Prospective, Double-Blind Evaluation of Umbilicopl...
-
▼
Νοε 28
(202)
- ► Σεπτεμβρίου (6470)
-
►
2016
(4179)
- ► Σεπτεμβρίου (638)
- ► Φεβρουαρίου (526)
- ► Ιανουαρίου (517)
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου