Abstract
In relapsing-remitting MS (RRMS) the symptoms of a clinical relapse subside over time. Neuroplasticity is believed to play an important compensatory role. In this study we assessed excitability-decreasing plasticity during an acute relapse of MS and 12 weeks afterwards. Motor plasticity was examined in 19 patients with clinically isolated syndrome or RRMS during a steroid-treated relapse (t1) and 12 weeks afterwards (t2) using paired-associative stimulation (PAS10). This method combines repetitive electric nerve stimulation with transcranial magnetic stimulation of the contralateral motor cortex to model long-term synaptic depression in the human cortex. Additionally, 19 age-matched healthy controls were assessed. Motor evoked potentials of the abductor pollicis brevis muscle were recorded before and after intervention. Clinical disability was assessed by the Multiple Sclerosis Functional Composite and the subscore of the nine-hole peg test taken as a measure of hand function. The effect of PAS10 was significantly different between controls and patients: At t1, but not at t2, baseline-normalized postinterventional amplitudes were significantly higher in patients (106 [IQR 98 – 137] % post10-15 and 111 [IQR 88-133] % post20-25) compared to controls (92 [IQR 85-111] % and 90 [IQR 75-102] %). Additional exploratory analysis indicated a potentially excitability-enhancing effect of PAS10 in patients as opposed to controls. Significant clinical improvement between t1 and t2 was not correlated with PAS10 effects.
Our results indicate an alteration of PAS10-induced synaptic plasticity during relapse, presumably reflecting a polarity shift due to metaplastic processes within the motor cortex. Further studies will need to elucidate the functional significance of such changes for the clinical course of MS.
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from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2pTkYa6
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