Effects of bilateral discectomy and bilateral discopexy on Black Merino Sheep rumination kinematics: TEMPOJIMS - pilot blinded, randomized preclinical study

Publication date: Available online 2 December 2017
Source:Journal of Cranio-Maxillofacial Surgery
Author(s): D.F. Ângelo, F. Monje, R. González, L. Monico, C. Moura, L. Francisco, D. Sanz, N. Alves, F. Salvado, P. Morouço
BackgroundThe potential for temporomandibular interposal materials is immense, but in order to progress in translational medicine, preclinical trials are essential. This temporomandibular joint interposal material study (TEMPOJIMS) is the first randomized, blinded, and controlled preclinical study (in line with the ARRIVE guidelines) of the TMJ domain.The normal process used by ruminants to break down dry matter involves initial chewing and rumination. This investigation focused on evaluating changes to this process after bilateral discectomy and discopexy.MethodsThis study was conducted using nine black Merino sheep to evaluate changes in chewing after bilateral discectomy and bilateral discopexy, by comparing with a sham surgery control group. The outcomes evaluated were: (1) absolute masticatory time; (2) ruminant time per cycle; (3) ruminant kinematics, and (4) ruminant area. After baseline evaluation and surgical interventions, the outcomes were recorded over 3 successive days, every 30 days, for 6 months.ResultsThe first month after intervention seemed to be the critical period for significant kinematic changes in the discectomy and discopexy groups. However, 6 months after the bilateral interventions, no significant changes were noticed when compared with the control group.ConclusionsThe introduction of kinematic evaluation presents a new challenge that may contribute to the improvement of future studies of the TMJ domain.



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