Publication date: Available online 2 December 2017
Source:Neuroscience Research
Author(s): Keita Fukumoto, Kota Tamada, Tsuyoshi Toya, Tasuku Nishino, Yuchio Yanagawa, Toru Takumi
During embryonic development, GABAergic interneurons, a main inhibitory component in the cerebral cortex, migrate tangentially from the ganglionic eminence (GE) to cerebral cortex. After reaching the cerebral cortex, they start to extend their neurites for constructing local neuronal circuits around the neonatal stage. Aberrations in migration or neurite outgrowth are implicated in neurological and psychiatric disorders such as epilepsy, schizophrenia and autism. Previous studies revealed that in the early phase of cortical development the neural population migrates tangentially from the GE in the telencephalon and several genes have been characterized as regulators of migration and specification of GABAergic interneurons. However, much less is known about the molecular mechanisms of GABAergic interneurons-specific maturation at later stages of development. Here, we performed genome-wide screening to identify genes related to the later stage by flow cytometry based-microarray (FACS-array) and identified 247 genes expressed in cortical GABAergic interneurons. Among them, Dgkg, a member of diacylglycerol kinase family, was further analyzed. Correlational analysis revealed that Dgkg is dominantly expressed in somatostatin (SST)-expressing GABAergic interneurons. The functional study of Dgkg using GE neurons indicated alteration in neurite outgrowth of GABAergic neurons. This study shows a new functional role for Dgkg in GABAergic interneurons as well as the identification of other candidate genes for their maturation.
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2yRDtOI
Αρχειοθήκη ιστολογίου
-
►
2023
(269)
- ► Φεβρουαρίου (133)
- ► Ιανουαρίου (136)
-
►
2022
(2046)
- ► Δεκεμβρίου (165)
- ► Σεπτεμβρίου (161)
- ► Φεβρουαρίου (165)
-
►
2021
(3028)
- ► Δεκεμβρίου (135)
- ► Σεπτεμβρίου (182)
- ► Φεβρουαρίου (324)
-
►
2020
(1051)
- ► Δεκεμβρίου (292)
- ► Σεπτεμβρίου (60)
- ► Φεβρουαρίου (28)
-
►
2019
(2277)
- ► Δεκεμβρίου (18)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (89)
-
►
2018
(26280)
- ► Δεκεμβρίου (189)
- ► Φεβρουαρίου (6130)
- ► Ιανουαρίου (7050)
-
▼
2017
(33948)
-
▼
Δεκεμβρίου
(6715)
-
▼
Δεκ 09
(161)
- Prevalence of soft tissue calcifications in the ma...
- The Clinical Use of Neuromuscular Electrical Stimu...
- Neuronal activity and outcomes from thalamic surge...
- Prior systemic treatment increased the incidence o...
- Complete response of a metastatic porocarcinoma tr...
- Antitumor miR-150-5p and miR-150-3p inhibit cancer...
- Early-onset childhood atopic dermatitis is related...
- Homelessness and Emergency Medicine: A Review of t...
- KRAS Testing, Tumor Location, and Survival in Pati...
- Reviewer Page
- NCCN News
- Prevalence of Physical Problems Detected by the Di...
- It's About Time!
- Controversies Regarding Use of Myeloid Growth Fact...
- Behavioral Economics and the Future of Biosimilars
- Champions Rising to the Challenge of Ensuring High...
- Radiosurgery for Brain Metastases: Changing Practi...
- Pazopanib Sensitivity in a Patient With Breast Can...
- Geographic Variation of Adjuvant Breast Cancer The...
- Ensuring Patient Safety and Access in Cancer Care
- A Patient Risk Model of Chemotherapy-Induced Febri...
- NCCN Guidelines Insights: Genetic/Familial High-Ri...
- Disparities in Adjuvant Endocrine Therapy
- Editorial Board
- Table of Contents
- Information for Authors
- Masthead
- Network-based brain stimulation selectively impair...
- Antitumor miR-150-5p and miR-150-3p inhibit cancer...
- Influence of involuntary cigarette smoke inhalatio...
- Identification of human papillomavirus (HPV) subty...
- Pattern of care and impact of prognostic factors o...
- Association between continuous positive airway pre...
- Conventional versus traction-assisted endoscopic s...
- Endoscopic detection rate of sessile serrated lesi...
- Time latencies of Helicobacter pylori eradication ...
- Safety and efficacy of lumen-apposing metal stents...
- Safety and Efficacy of guselkumab in Japanese pati...
- Which outcomes are reported in cellulitis trials? ...
- Auras and the risk of seizures with impaired consc...
- Pattern of care and impact of prognostic factors o...
- Gongylonema pulchrum infection in the human oral c...
- Quality and readability of internet-based informat...
- Identification of human papillomavirus (HPV) subty...
- Aging Decreases Chorda-Tympani Nerve Responses to ...
- Localizing Speakers in Multiple Rooms by Using Dee...
- Rank-1 constrained Multichannel Wiener Filter for ...
- Neural versus phrase-based MT quality: An in-depth...
- Situated reference resolution using visual salienc...
- Audio-visual word prominence detection from clean ...
- Synthetic speech detection using fundamental frequ...
- Predicting speech intelligibility with deep neural...
- Application of the pairwise variability index of s...
- Automatic orthographic error tagging and classific...
- Assessment of pitch-adaptive front-end signal proc...
- Speaker and Language Recognition and Characterizat...
- Conversational telephone speech recognition for Li...
- Learning static spectral weightings for speech int...
- American Journal of Cancer Research; +19 new citat...
- Bilateral sequential peripheral vestibulopathy.
- Expanding the use of abiraterone in prostate cance...
- Multispectral imaging reveals hyper active TGF-β s...
- The levels of mutant K-RAS and mutant N-RAS are ra...
- Modulating secreted components of tumor microenvir...
- Expanding the use of abiraterone in prostate cance...
- Multispectral imaging reveals hyper active TGF-β s...
- The levels of mutant K-RAS and mutant N-RAS are ra...
- Modulating secreted components of tumor microenvir...
- The development of the human hyoid-larynx complex ...
- Toxicity trial of canine posterior cricoarytenoid ...
- Improved adductor function after canine recurrent ...
- Mucous Membrane Pemphigoid with Ocular Involvement...
- Diagnostic and treatment effects of sialendoscopy ...
- Exploring Multiphoton Microscopy as a Novel Tool t...
- Next-Generation Sequencing Approach to Non-Small C...
- [Gut microbiota: What impact on colorectal carcino...
- Costs and effectiveness of hearing conservation pr...
- Costs and effectiveness of hearing conservation pr...
- Expanding the use of abiraterone in prostate cance...
- Multispectral imaging reveals hyper active TGF-β s...
- The levels of mutant K-RAS and mutant N-RAS are ra...
- Modulating secreted components of tumor microenvir...
- Track to the future: historical perspective on the...
- Social cognition and aggression in methamphetamine...
- The development and validation of the speech quali...
- Impact of diabetes on free flap surgery of the hea...
- Intracranial Anatomical Triangles: A Comprehensive...
- Intranasal Esthesioneuroblastoma: CT Patterns Aid ...
- Clinical, molecular, and computational analysis in...
- Lipid bilayer mediates ion-channel cooperativity i...
- Lipid bilayer mediates ion-channel cooperativity i...
- Cyclic fatigue and torsional strength of three dif...
- Relationship between caries experience and demarca...
- FTO Gene Affects Obesity and Breast Cancer Through...
- Elevated Serum Vitamin B12 Levels as a Prognostic ...
- Differences between osteoradionecrosis and medicat...
- American Journal of Cancer Research; +19 new citat...
- How fast can treatment with overdentures improve t...
- Long-Lasting Dysphagia Developing After Thoracotom...
- How fast can treatment with overdentures improve t...
-
▼
Δεκ 09
(161)
- ► Σεπτεμβρίου (6470)
-
▼
Δεκεμβρίου
(6715)
-
►
2016
(4179)
- ► Σεπτεμβρίου (638)
- ► Φεβρουαρίου (526)
- ► Ιανουαρίου (517)
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου