Survival of Staphylococcus epidermidis in Propofol and Intralipid in the Dead Space of Intravenous Injection Ports

We tested whether propofol or Intralipid inoculated with Staphylococcus epidermidis would promote bacterial growth within an intravenous (IV) injection hub, a site prone to bacterial contamination. In tubes incubated under optimal conditions, S epidermidis exhibited growth in Intralipid, but not in propofol. In contrast, within the IV hub incubated with either propofol or intralipid at room temperature, S epidermidis bacterial numbers declined with time, and virtually no contamination remained after 12 hours. These data suggest that certain IV lines are inhospitable for S epidermidis. Accepted for publication October 9, 2017. The authors Noble, Salim, Gragasin, and Bourque contributed equally to this study. Funding: This study was supported by funds from the Canadian Institutes of Health Research (MOP142396 to S.L.B. and MOP142446 to F.S.G.), and the Department of Anesthesiology & Pain Medicine at the University of Alberta. The authors declare no conflicts of interest. S. L. Bourque and F. S. Gragasin contributed equally to this work. Reprints will not be available from the authors. Address correspondence to Stephane L. Bourque, PhD, Department of Anesthesiology & Pain Medicine, 3-020H Katz Group Centre for Pharmacy and Health Research, University of Alberta, Edmonton, AB T6G 2E1, Canada. Address e-mail to sbourque@ualberta.ca. © 2017 International Anesthesia Research Society

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