Carotid arteritis causing amaurosis fugax and ischaemic cerebrovascular events in neurosarcoidosis

Publication date: Available online 22 March 2018
Source:Clinical Neurology and Neurosurgery
Author(s): D.P. Kidd, D.J. McCabe, T. Wilhelm, M. Galloway
ObjectiveTo present and review the vascular consequences of arteritis in neurosarcoidosis.Patient and methods: neurosarcoidosis is typically an inflammatory disorder of the meninges surrounding the brain and spinal cord. Although inflammation of small and medium sized vessels is seen pathologically and vasculitis is occasionally described, a large intracerebral arteritis has not previously been reported. A few case reports exist, however, which describe the vascular consequences of large vessel compromise in the disorder. We review the literature and present a new case with novel MRI features which imply carotid arteritis.ResultsThe case presented with a disorder of the carotid artery on one side leading to a series of TIAs. Inflammation of the wall of the carotid artery was seen adjacent to a granulomatous leptomeningitis. The disorder responded to immunosuppressive therapy without recurrence.ConclusionsThe imaging features suggest a granulomatous infiltration of the carotid artery wall leading to arteritis followed by disorganisation of the internal elastic lamina and fibrosis. The data provide further insight into the pathogenesis of neurological impairments in neurosarcoidosis. The MRI features of carotid arteritis in neurosarcoidosis have not previously been demonstrated.



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