Age and gender differences in mechanically induced intra oral temporal summation and conditioned pain modulation in healthy subjects.

Publication date: Available online 13 April 2018
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Junad Khan, Olga Korczeniewska, Rafael Benoliel, Mythili Kalladka, Eli Eliav, Cibelle Nasri-Heir
ObjectiveTo study intra oral Temporal Summation (TS) and Conditioned Pain Modulation (CPM) and compare the outcome to TS and CPM induced in the forearm. Also, to study the effect of age and gender on intra oral and forearm TS and CPM.Study DesignMechanical stimulation was induced with # 5.46 von Frey filament applying 26 grams of force. A single stimulus, and then a train of 30 successive stimuli were applied intra orally and to the dominant forearm. CPM was assessed with TS test as the painful stimulus and non-dominant hand immersion in hot water bath as the conditioning stimulus.ResultsGender was significantly associated with TS but not CPM measures. Females had significantly lower mean TS measured in the face and in dominant forearm than males. Age was significantly associated with CPM but not TS measures. In both sites examined, older subjects had significantly lower mean CPM when compared to younger subjects.ConclusionMechanical temporal summation elicited in the oral cavity can be used as test-stimulus for CPM testing. Intraoral modulation, both TS and CPM has a similar extent to that of the standard cutaneous extremity. TS was lower in females and CPM reduced with age.



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