Association between nasopharyngeal carcinoma and risk of optic neuropathy: A population-based cohort study.

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Association between nasopharyngeal carcinoma and risk of optic neuropathy: A population-based cohort study.

Head Neck. 2018 Apr 16;:

Authors: Fan CY, Jen YM, Su YC, Chao HL, Lin CS, Huang WY, Lin MJ, Kao CH

Abstract
BACKGROUND: The purpose of this study was to assess the predictive factors of optic neuropathy among patients with nasopharyngeal carcinoma (NPC).
METHODS: The analysis included 16 297 patients with NPC and 65 187 controls. Each patient with NPC was randomly frequency-matched with 4 individuals without NPC by age, sex, and index year. Cox proportional hazard models were applied to measure the hazard ratios (HRs) and 95% confidence intervals (CIs) of optic neuropathy development associated with NPC.
RESULTS: The risk of optic neuropathy was significantly higher in the NPC cohort (adjusted HR [aHR] 3.42; 95% CI 2.85-4.09; P < .001). Independent risk factors for optic neuropathy among patients with NPC included stroke (aHR 1.7; 95% CI 1.07-2.7; P = .03) and receipt of chemotherapy (aHR 1.55; 95% CI 1.17-2.06; P = .002).
CONCLUSION: The risk of optic neuropathy was significantly higher in patients with NPC than in the general population.

PMID: 29663564 [PubMed - as supplied by publisher]

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