CSF ferritin predicts CSF A{beta} decline in biomarker-determined Alzheimers disease

CSF ferritin relationship to CSF Aβ could be used to identify AD patients for iron chelation therapy

This JNNP paper by an excellent team of investigators1 has built on many years of study that has shown loss of iron homeostasis in brain of persons with Alzheimer's disease (AD). As the authors pointed out, iron has been identified with amyloid plaques and has been suggested to promote neurodegenerative processes through inflammation and generation of oxidative stress.2 There is also a considerable literature on  amyloid precursor protein (APP) and iron handling in the brain including the presence of an iron-responsive element on the APP messenger RNA.3 Therefore, iron is clearly implicated in AD pathology and pathogenic processes.

Using cerebrospinal fluid (CSF) ferritin as a surrogate marker for brain iron status is supported by a number of studies cited in the manuscript. The authors address the possibility that CSF ferritin...

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader https://ift.tt/2JDbHZC