LINC00673 silencing inhibits cell migration and invasion by suppressing PI3K/AKT signaling in glioma

LINC00673 is an oncogene that plays a key role in various cancer types. However, the role of LINC00673 in glioma remains unclear. In this study, we examined its expression in glioma cells by quantitative real-time PCR and found higher expression of LINC00673 in glioma cells compared with that in normal human astrocytes. Furthermore, LINC00673 silencing inhibited the migration and invasion of U87MG and U118MG cells, phosphoinositide 3-kinase (PI3K) expression, and AKT phosphorylation. Moreover, activation of the PI3K/AKT signaling pathway by insulin-like Growth factor-1 abolished the inhibitory effect of LINC00673 silencing on the migration and invasion of U87MG and U118MG cells. In conclusion, LINC00673 silencing inhibits glioma cell migration and invasion by suppressing the PI3K/AKT signaling pathway, and it is a potential therapeutic target for the treatment of metastatic glioma. *Feng Zhang, Yuen Huang, and Bata Wang contributed equally to the writing of this article. Correspondence to Shanshan Ding, MD, College of Chinese Language and Culture, Jinan University, No. 377, Shougouling Road, Tianhe District, Guangzhou 510610, People's Republic of China Tel: +86 159 8911 46322; fax: +86 020 3868 8617; e-mail: 704438186@qq.com Received January 31, 2018 Accepted March 6, 2018 © 2018 Wolters Kluwer Health | Lippincott Williams & Wilkins

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