Abstract Background Research into drug hypersensitivity associated with expression of specific HLA alleles has focussed on the interaction between parent drug and the HLA with no attention given to reactive metabolites. For this reason, we have studied HLA‐B*13:01‐linked dapsone hypersensitivity to (1) explore whether the parent drug and/or nitroso metabolite activates T‐cells and (2) determine whether HLA‐B*13:01 is involved in the response. Methods PBMC from 6 patients were cultured with...
Thu Mar 07, 2019 15:45
Wed Mar 06, 2019 15:28
Abstract Drug hypersensitivity reactions (DHR) are based on distinct mechanisms and are clinically heterogeneous. Taking into account that also off target activities of drugs may lead to stimulations of immune or inflammatory cells, three forms of DHR were discriminated: The allergic‐immune mechanism relies on the covalent binding of drugs/chemicals to proteins, which thereby form new antigens, to which a humoral and/or cellular immune response can develop. In IgE mediated drug allergies a possible...
Wed Mar 06, 2019 15:15
Abstract Coconut oil is used as a dietary oil worldwide, and its healthy effects are recognized by the fact that coconut oil is easy to digest, helps in weight management, increases healthy cholesterol and provides instant energy. Although topical application of coconut oil is known to reduce skin infection and inflammation, whether dietary coconut oil has any role in decreasing skin inflammation is unknown. In this study, we showed the impact of dietary coconut oil in allergic skin inflammation...
Wed Mar 06, 2019 15:15
Abstract Biodiversity hypothesis states, that contact with natural environments enriches the human microbiome, promotes immune balance and protects from allergy and inflammatory disorders. We are protected by two nested layers of biodiversity, microbiota of the outer layer (soil, natural waters, plants, animals) and inner layer (gut, skin, airways). The latter inhabits our body and is colonized from the outer layer. Explosion of human populations along with cultural evolution are profoundly changing...
Tue Mar 05, 2019 11:24
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