Cancers, Vol. 12, Pages 3377: Tumor Microenvironment and Immunotherapy Response in Head and Neck Cancer

Alexandros G.Sfakianakis shared this article with you from Inoreader Cancers, Vol. 12, Pages 3377: Tumor Microenvironment and Immunotherapy Response in Head and Neck Cancer Μέσω Cancers Cancers, Vol. 12, Pages 3377: Tumor Microenvironment and Immunotherapy Response in Head and Neck Cancer Cancers doi: 10.3390/cancers12113377 Authors: Panagiota Economopoulou Ioannis Kotsantis Amanda Psyrri The tumor microenvironment (TME) encompasses cellular and non-cellular components which play an important role in tumor evolution, invasion, and metastasis. A complicated interplay between tumor cells and adjacent TME cells, such as stromal cells, immune cells, inflammatory cells, and cytokines, leads to severe immunosuppression and the proliferation of cancer cells in several solid tumors. An immunosuppressive TME has a significant impact on treatment resistance and may guide response to immunotherapy. In head and neck cancer (HNC), immunotherapeutic drugs have been incorporated in everyday clinical practice. However, despite an exceptional rate of durable responses, only a low percentage of patients respond. In this review, we will focus on the complex interactions occurring in this dynamic system, the TME, which orchestrate key events that lead to tumor progression, immune escape, and resistance. Furthermore, we will summarize current clinical trials that depict the TME as a p otential therapeutic target for improved patient selection. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.