Cumulative suppressive index as a predictor of relapse free survival and overall survival in Human Papilloma Virus‐negative oral squamous cell carcinomas with negative resection margins

xlomafota13 shared this article with you from Inoreader Cumulative suppressive index as a predictor of relapse free survival and overall survival in Human Papilloma Virus‐negative oral squamous cell carcinomas with negative resection margins Via Head & Neck Abstract Background This study aimed to analyze margin status and the impact of the immune elements on recurrence in patients with oral squamous cell carcinoma (OSCC), employing a prognostic biomarker, cumulative suppressive index (CSI), which reflects FoxP3+, PD‐L1+, and CD8+ cell spatial relationships in the tumor microenvironment. Methods Cox proportional hazards regression was used to evaluate the interactive effect of the margin by CSI discrepancy (high, 3‐4 vs low, 0‐2) on recurrence free survival (RFS) and overall survival (OS) in 119 patients with stage I to IVA OSCC. Results In cases with negative margins, multivariable analysis showed high CSI was significantly associated with worse RFS (HR = 2.59, 95% CI [1.03, 6.49], P = .04) and OS (HR = 5.49, 95% CI [1.48, 20.35], P = .01) compared to low CSI. However, high CSI was not significantly associated with recurrence in cases with positive margins. Conclusions Immune architecture analysis can augment our current histopathological risk assessment of margin status. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.