Translational Critical Care Medicine

Cerebral Venous Thrombosis in Air Travelers during COVID-19 Times: Is the Risk Higher? Luis Rafael Moscote-Salazar, Tariq Janjua, Pilar Bosque-Varela, Amit Agrawal Journal of Translational Critical Care Medicine 2020 2(3):47-48

Research Progress on Sepsis-Related Liver Injury Kai Kang, Na-Na Li, Yang Gao, Xue Du, Xin-Yu Zhang, Ming-Yan Zhao, Kai-Jiang Yu Journal of Translational Critical Care Medicine 2020 2(3):49-53 Liver injury is one of the most common critical clinical illnesses and is one of the manifestations of multiple organ dysfunction induced by sepsis. The liver plays a central role in the development of sepsis. The role of the liver in removing bacteria and regulating immune inflammation is crucial, and the liver is the target of sepsis-related injuries. However, the mechanism of liver injury in sepsis is still not clear. This review discusses the pathophysiology, clinical manifestations, and treatment of sepsis-related liver injury. Liver injury, pathophysiological mechanism, sepsis, sepsis-related liver injury

Endoplasmic Reticulum Stress and Critical Care Medicine Ying Shi, Tingting Wang, Xiangrong Zuo Journal of Translational Critical Care Medicine 2020 2(3):54-63 Many patients suffer from multiple organ dysfunction syndrome (MODS), which represents a dominant cause of death in the intensive care unit. Current theories about the mechanisms of MODS include inflammation, dysregulated immune response, reduced cellular oxygen utilization, cytopathic hypoxia, and apoptosis. Moreover, an increasing number of studies have shown that endoplasmic reticulum stress (ERS) is related to organ dysfunction. The endoplasmic reticulum is an organelle that is responsible for secretion and membrane protein synthesis and assembly as well as some other physiological activities. Under certain conditions, the homeostasis of ER can be lost, causing the accumulation of unfolded or misfolded protein, which is termed as ERS. During ERS, unfolded protein response (UPR) is activated. Once UPR fails to rebuilt cellular homeostasis, cell function will be impaired and apoptosis will be induced. To better understand the relationship between ERS and severe diseases, we summarize the current research in the context of ERS and UPR signaling associated with various organ dysfunction and severe diseases, including acute lung injury, hepatic injury, heart failure, hemorrhagic shock with multiple organ dysfunction, sepsis, and some other diseases. We also discuss ERS or UPR as a novel therapeutic target and their future directions.

D Vitamin, Coronavirus, and Neurological Injuries William Andres Florez Perdomo, Harold Enrique Vásquez Ucros, Luis Rafael Moscote-Salazar Journal of Translational Critical Care Medicine 2020 2(3):64-65

Patients Admitted to the Intensive Care Unit Should Receive Central Venous Pressure Monitoring: We Should Personalize Our Approach Patrick M Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels Journal of Translational Critical Care Medicine 2020 2(3):66-66

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

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