Efficacy of Trimetazidine Dihydrochloride for Relieving Chronic Tinnitus: A Randomized Double-Blind Study.

Efficacy of Trimetazidine Dihydrochloride for Relieving Chronic Tinnitus: A Randomized Double-Blind Study.

Clin Exp Otorhinolaryngol. 2016 May 27;

Authors: Kumral TL, Yıldırım G, Berkiten G, Saltürk Z, Ataç E, Atar Y, Uyar Y

Abstract
Objectives: To evaluate the efficacy of trimetazidine dihydrochloride as a treatment for chronic tinnitus.
Methods: A total of 97 chronic tinnitus patients were evaluated in this randomized, prospective, double-blind, placebo-controlled trial. After assessing for eligibility, 82 patients were randomly assigned into placebo or trimetazidine groups according to the medication. The trimetazidine group received 20×3 mg/day per oral trimetazidine dihydrochloride and the placebo group received 20×3 mg/day per oral placebo for 3 months. Tinnitus handicap inventory (THI), visual analogue scale (VAS) questionnaires and audiometric.
Results.: were used to determine the effectiveness of trimetazidine treatment.
Results: The study group comprised 82 tinnitus subjects, 42 (51.2%) of whom received trimetazidine dihydrochloride and 40 (48.8%) who received placebo. There was no significant difference between placebo and trimetazidine groups in THI grade and VAS (both pre- and posttreatment scores) (P>0.05) and no significant improvement was observed in subjective loudness score in either group (P>0.05). Additionally there was no significant difference between groups in pre- and posttreatment pure tone hearing thresholds at all measured frequencies (P>0.05).
Conclusion: Trimetazidine dihydrochloride therapy was ineffective for relieving chronic tinnitus.

PMID: 27230273 [PubMed - as supplied by publisher]

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