Hydrops of the organ of Corti.

Hydrops of the organ of Corti.

Acta Otolaryngol. 2016 May 31;:1-3

Authors: Nomura Y, Kimura Y, Kobayashi H

Abstract
OBJECTIVES: The authors would like to confirm a fluid pathway from the scala tympani to the organ of Corti, and to observe its morphological changes.
METHODS: A staining solution for succinic dehydrogenase was perfused with phenazine methosulfate in the scala tympani of living guinea pigs (n = 5) under deep anesthesia. After fixation, the cochleas were eventually embedded in epon. Sections were observed under a light microscope.
RESULTS: Blue-stained tissue is indicative of the pathway taken by the solution. The staining solution entered the organ of Corti through Hensen-Deiters' slit. The slit widened and Hensen's cells were pushed laterally. A new space was formed medial to Hensen's cells. Cortilymphatic hydrops developed.
CONCLUSION: The Hensen-Deiters' slit is a pathway of a certain staining solution from the scala tympani to inside the organ of Corti of the guinea pig. The influx of the fluid pushes Hensen's cells laterally and upward, resulting in a formation of hydrops of the organ of Corti or cortilymphatic hydrops. The hydrops is observed in animals with experimental perilymphatic fistula and with viral labyrinthitis. At the end stage of the hydrops, only the surface of the organ of Corti remains as a thin layer without any cellular elements.

PMID: 27241920 [PubMed - as supplied by publisher]

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