Adipose stromal cells improve healing of vocal fold scar: Morphological and functional evidences.

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Adipose stromal cells improve healing of vocal fold scar: Morphological and functional evidences.

Laryngoscope. 2016 Aug;126(8):E278-85

Authors: de Bonnecaze G, Chaput B, Woisard V, Uro-Coste E, Swider P, Vergez S, Serrano E, Casteilla L, Planat-Benard V

Abstract
OBJECTIVES/HYPOTHESIS: Adipose derived stromal cells (ASCs) are abundant and easy to prepare. Such cells may be useful for treating severe vocal disturbance caused by acute vocal fold scars.
STUDY DESIGN: Prospective animal experiments with controls.
METHODS: Twenty New-Zealand white rabbits were used in the present study. We evaluated vocal fold healing, with or without injection of autologous ASCs, after acute scarring. A defined lesion was created and the ASCs were immediately injected. Vocal fold regeneration was evaluated histomorphometrically and via viscoelastic analysis using an electrodynamic shaker.
RESULTS: Six weeks after ASC injection, vocal folds exhibited significantly less inflammation than control folds (P < 0.005). In addition, hypertrophy of the lamina propria and fibrosis were significantly reduced upon ASC injection (P < 0.02). The decrease in viscoelastic parameters was less important in the ASC injected group compared to the noninjected group (P = 0.08).
CONCLUSION: Injection of autologous ASCs improved vocal fold healing in our preclinical model. Further studies are needed, but this method may be useful in humans.
LEVEL OF EVIDENCE: NA. Laryngoscope, 126:E278-E285, 2016.

PMID: 27075408 [PubMed - indexed for MEDLINE]

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