Sensitivity and Specificity of Clinical and Laboratory Otolith Function Tests.

Sensitivity and Specificity of Clinical and Laboratory Otolith Function Tests.

Otol Neurotol. 2017 Aug 08;:

Authors: Kumar L, Thakar A, Thakur B, Sikka K

Abstract
OBJECTIVE: To evaluate clinic based and laboratory tests of otolith function for their sensitivity and specificity in demarcating unilateral compensated complete vestibular deficit from normal.
STUDY DESIGN: Prospective cross-sectional study.
SETTING: Tertiary care hospital vestibular physiology laboratory.
SUBJECTS: Control group-30 healthy adults, 20-45 years age; Case group-15 subjects post vestibular shwannoma excision or post-labyrinthectomy with compensated unilateral complete audio-vestibular loss.
INTERVENTION: Otolith function evaluation by precise clinical testing (head tilt test-HTT; subjective visual vertical-SVV) and laboratory testing (headroll-eye counterroll-HR-ECR; vesibular evoked myogenic potentials-cVEMP).
MAIN OUTCOME MEASURE: Sensitivity and specificity of clinical and laboratory tests in differentiating case and control subjects.
RESULTS: Measurable test results were universally obtained with clinical otolith tests (SVV; HTT) but not with laboratory tests. The HR-ECR test did not indicate any definitive wave forms in 10% controls and 26% cases. cVEMP responses were absent in 10% controls.HTT test with normative cutoff at 2 degrees deviations from vertical noted as 93.33% sensitive and 100% specific. SVV test with normative cutoff at 1.3 degrees noted as 100% sensitive and 100% specific. Laboratory tests demonstrated poorer specificities owing primarily to significant unresponsiveness in normal controls.
CONCLUSIONS: Clinical otolith function tests, if conducted with precision, demonstrate greater ability than laboratory testing in discriminating normal controls from cases with unilateral complete compensated vestibular dysfunction.

PMID: 28796086 [PubMed - as supplied by publisher]

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