The Significance of L1CAM Expression in Clear Cell Carcinoma of the Endometrium

Abstract

Clear cell carcinoma is an uncommon histotype of endometrial carcinoma, representing less than 1% of cases (1). Although clear cell carcinoma is generally considered to be a clinically aggressive, "high risk" cancer (2), reported patient outcomes have been markedly variable at every stage of disease (3-8), possibly reflecting an underlying biologic heterogeneity that is inherent to the histotype (9). Indeed, somatic mutation profiling of cases classified as clear cell carcinoma have shown them to be markedly heterogeneous at the molecular level, with subsets resembling serous carcinomas, endometrioid carcinoma, neither, or both (10-12).

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