Decreased peritumoral CD1a+ cells predicts worse prognosis in oral squamous cell carcinoma

Abstract

Background

Dendritic cells (DCs) are known to play a central role in the regulation of both innate and adaptive immunologic responses, including antitumor immunity. This study aimed to evaluate the prognostic impact of intra and peritumoral dendritic cells in oral squamous cell carcinoma (OSCC) affecting tongue and floor of the mouth.

Patients and Methods

Immunohistochemical reactions for CD1a and CD83 were performed in 53 patients with OSCC in tongue and floor of the mouth. The markers were evaluated by automated examination in intratumoral and stromal compartments and the results were expressed as the density of cells per mm². These data underwent correlation with clinicopathological and survival outcomes.

Results

Depletion of stromal CD1a+ had association with lymph node metastasis (p = 0.05), whereas the diminished density of stromal CD83+ were correlated with smoking history (p = 0.04), lymph node metastasis (p = 0.015) and extracapsular spread of lymph nodes (p = 0.018). Stromal CD1a+ was correlated with recurrence (p= 0.007) and overall survival (p= 0.03). Results from the survival analysis using the Cox proportional hazard model has shown that decreased number of stromal CD1a+ is an independent factor for overall survival and disease-free survival.

Conclusion

Our results suggest that the depletion of number of peritumoral CD1a+ cells is a strong independent prognostic factor, reflecting in higher recurrence rates and lower survival outcomes.

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from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2zfbdn1