Abstract
Aims
Xanthogranulomatous cholecystitis (XGC), an unusual histologic variant of chronic cholecystitis, is characterized by mixed foamy histiocytic and lymphoplasmocytic infiltration and fibrosis. Radiologically, the poorly defined nodular growth pattern often leads to the misinterpretation of XGC as gallbladder cancer. In this study, we aimed to identify the relationship of XGC with IgG4-related cholecystitis,
Methods and Results
We re-evaluated 57 surgically resected XGCs and 104 conventional chronic cholecystitis cases, according to the histologic features observed in IgG4-related disease, including lymphoplasmocytic infiltration, storiform fibrosis, obliterative phlebitis, and IgG4-positive plasma cells. XGCs contained a significantly increased mean number of IgG4-positive plasma cells (34.8/high-power field [HPF]), compared with conventional chronic cholecystitis (4.8/HPF; P < .001), and 16 XGCs (28%) harbored >50 IgG4-positive cells per HPF. Nine XGCs (16%), including one case with IgG4-related autoimmune pancreatitis, exhibited "the histological features suggestive of IgG4-related disease", as described in the consensus statement regarding this condition. Extracholecystic inflammatory extension (7 cases, P = .009) and mass-forming lesions (8 cases, P < .001) were more frequently seen in XGC cases with histological features suggestive of IgG4-related disease than in cases without those microscopic changes.
Conclusions
XGCs with IgG4-positive cell infiltration are considered mimickers, as xanthogranulomatous inflammation generally contradicts a diagnosis of IgG4-related disease and is weakly associated with other typical organ manifestations of IgG4-related disease. However, XGC may be a concurrent condition, particularly in patients with IgG4-related disease in other organs.
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from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2yZ8uNA
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