Serum and sputum calprotectin, a reflection of neutrophilic airway inflammation in asthmatics after high altitude exposure

Abstract

Until recently, asthma has been characterized as a T(h)2-disorder with eosinophilic airway inflammation. However, several studies showed the existence of patients with asthma characterized by neutrophilic airway inflammation.[1] Seys et al. showed an increased proportion of sputum neutrophils in asthmatic patients after exposure to environmental conditions at high altitude (HA) and in elite athletes after intensive exercise (swimming).[2,3] As patients with neutrophilic asthma poorly respond to classic therapies such as inhaled corticosteroids, it is crucial to identify these patients to predict their medication response and to provide them with an appropriate therapy.[4]

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