Human plasma C3 is essential for the development of memory B, but not T, lymphocytes

Publication date: Available online 4 November 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Anaïs Jiménez-Reinoso, Ana V. Marin, Marta Subias, Alberto López-Lera, Elena Román-Ortiz, Kathryn Payne, Cindy S. Ma, Giuseppina Arbore, Martin Kolev, Simon J. Freeley, Claudia Kemper, Stuart G. Tangye, Edgar Fernández-Malavé, Santiago Rodríguez de Córdoba, Margarita López-Trascasa, José R. Regueiro

Teaser

Primary or secondary plasma C3 deficiency due to mutations in C3 or in complement Factor I impairs memory B, but not T, cell differentiation, but does not preclude intracellular C3 fragment expression in lymphocytes.


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