The nuclear receptor PPAR-β/δ (PPARD) has essential roles in fatty acid catabolism and energy homeostasis as well as cell differentiation, inflammation and metabolism. However, its contributions to tumorigenesis are uncertain and have been disputed. Here we provide evidence of tumor suppressive activity of PPARD in prostate cancer through a non-canonical and ligand-independent pathway. PPARD was downregulated in prostate cancer specimens. In murine prostate epithelium, PPARD gene deletion resulted in increased cellularity. Genetic modulation of PPARD in human prostate cancer cell lines validated the tumor suppressive activity of this gene in vitro and in vivo. Mechanistically, PPARD exerted its activity in a DNA binding-dependent and ligand-independent manner. We identified a novel set of genes repressed by PPARD that failed to respond to ligand-mediated activation. Among these genes, we observed robust regulation of the secretory trefoil factor family (TFF) members, including a causal and correlative association of TFF1 to prostate cancer biology in vitro and in patient specimens. Overall, our results illuminate the oncosuppressive function of PPARD and understanding of the pathogenic molecular pathways elicited by this nuclear receptor.
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2Anjrgt
Αρχειοθήκη ιστολογίου
-
►
2023
(269)
- ► Φεβρουαρίου (133)
- ► Ιανουαρίου (136)
-
►
2022
(2046)
- ► Δεκεμβρίου (165)
- ► Σεπτεμβρίου (161)
- ► Φεβρουαρίου (165)
-
►
2021
(3028)
- ► Δεκεμβρίου (135)
- ► Σεπτεμβρίου (182)
- ► Φεβρουαρίου (324)
-
►
2020
(1051)
- ► Δεκεμβρίου (292)
- ► Σεπτεμβρίου (60)
- ► Φεβρουαρίου (28)
-
►
2019
(2277)
- ► Δεκεμβρίου (18)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (89)
-
►
2018
(26280)
- ► Δεκεμβρίου (189)
- ► Φεβρουαρίου (6130)
- ► Ιανουαρίου (7050)
-
▼
2017
(33948)
- ► Δεκεμβρίου (6715)
-
▼
Νοεμβρίου
(6500)
-
▼
Νοε 29
(187)
- Patient-specific puzzle implant preformed with 3d-...
- Option grids in melanoma - an underused tool
- Effect of carpal tunnel release on median nerve ep...
- BranchAnalysis2D/3D automates morphometry analyses...
- Giant cell tumor of temporomandibular joint presen...
- Primary cutaneous aspergillosis, mimicking maligna...
- Implementing noninvasive follicular thyroid neopla...
- Epidemiology, biology and therapy of Merkel cell c...
- Epidemiology, biology and therapy of Merkel cell c...
- Randomized Split-face, Controlled Comparison of Tr...
- Exercise Alters Gut Microbiota Composition and Fun...
- Adipose Lipolysis Unchanged by Preexercise Carbohy...
- Biological/Genetic Regulation of Physical Activity...
- Strength, Affect Regulation, and Subcortical Morph...
- Cardiometabolic Impact of Changing Sitting, Standi...
- SoftHand at the CYBATHLON: a user’s experience
- The extent of surgery for benign parotid pathology...
- Acute Chest Syndrome: An Ongoing Challenge for Phy...
- Diet, Lung Function, and Asthma Exacerbations in P...
- Neutrophil–Lymphocyte Ratio in Children with Recur...
- Developing a Mobile Health Intervention for Low-In...
- Epidemiology, biology and therapy of Merkel cell c...
- Model of a bilateral Brown-type central pattern ge...
- The assessment of neurovascular coupling with the ...
- Ih Interacts with Somato-Dendritic Structure to De...
- Time course of functional recovery during first th...
- Clustering of Heading Selectivity and Perception-R...
- Complementary metrics of human auditory nerve func...
- Implantable computer-controlled adaptive multi-ele...
- Quantitative relations between BOLD responses, cor...
- Estimating properties of the fast and slow adaptiv...
- Quantitative input: output relationships between h...
- Effect of Sensory Attenuation on Cortical Movement...
- Modeling spatial navigation in the presence of dyn...
- Outcomes of Children and Adolescents with Advanced...
- PTBP3-mediated regulation of ZEB1 mRNA stability p...
- Modeling the subclonal evolution of cancer cell po...
- HER2-driven Breast Tumorigenesis Relies upon Inter...
- LSR antibody therapy inhibits ovarian epithelial t...
- Photodynamic priming mitigates chemotherapeutic se...
- The E3 ligase RING1 targets p53 for degradation an...
- Delivering type I interferon to dendritic cells em...
- PPAR{delta} elicits ligand-independent repression ...
- Disparities in Prostate, Lung, Breast, and Colorec...
- Which Preschool Children With Specific Language Im...
- Re-irradiation for recurrent glioma- the NCI exper...
- Index
- Errata
- Errata
- Errata
- Irinotecan and Oxaliplatin Might Provide Equal Ben...
- Robotic-assisted Transperitoneal Infrarenal Para-a...
- Anastomotic Leakage Using Linear Stapling Device w...
- A Glissonean Approach with Individual Isolation Du...
- Mucinous Cystic Neoplasms Lined by Abundant Mucino...
- Outcome Evaluation of HER2 Breast Cancer Patients ...
- Characterization of Prognostic Factors and the Eff...
- FOLFOX as First-line Therapy for Gastric Cancer wi...
- Incidence and Risk Factors of Symptomatic Hiatal H...
- A Prospective Study of Intensity-modified Radiatio...
- Pancreatic Mucinous Cystic Neoplasm Communicating ...
- Predictive Factors and a Survival Score for Patien...
- Making and working of a new electronic resource fo...
- Nodular fasciitis of the temporomandibular joint: ...
- Prognosis of oral cancer: a comparison of the stag...
- Is it better to bend wires occlusally or apically ...
- Retroseptal transconjunctival approach for fractur...
- Tracking the Growth of Tense and Agreement in Chil...
- Evaluation of an Automated Pipeline for Large Scal...
- Option grids in melanoma - an underused tool
- Effect of carpal tunnel release on median nerve ep...
- Patient-specific puzzle implant preformed with 3d-...
- The extent of surgery for benign parotid pathology...
- Comparing Traditional Service Delivery and Telepra...
- Effects of platelet-rich plasma on pain and muscle...
- The effect of stretching combined with ultrashort ...
- Uterus transplantation: A Rapidly Expanding Field
- Categorizing coordination from the perception of j...
- Phlebotomy as a preventive measure for crocidolite...
- Oral cancer databases: a comprehensive review
- Frankophonie im Plural
- "Manuel des francophonies" published by De Gruyter
- Plurielles Francophonies
- EM Nerd-The Case of Corporeal Clock
- A survival analysis using physique-adjusted tumor ...
- Are rehabilitation outcomes after severe anoxic br...
- Measuring quality of life in individuals with Park...
- Cicatricial Organizing Pneumonia Mimicking a Fibro...
- Heterozygosity for the Mood Disorder-Associated Va...
- Enhancing Memory Consolidation through Slow Oscill...
- Phosphoinositol-4,5-Bisphosphate Regulates Auditor...
- Exploring the Role of CaMKIV in Homeostatic Plasti...
- Neuromedin B Expression Defines the Mouse Retrotra...
- Trafficking of Kv2.1 Channels to the Axon Initial ...
- Optogenetic Activation of the fruitless-Labeled Ci...
- Optogenetic Inhibition Reveals Distinct Roles for ...
- Frontal Eye Field Inactivation Diminishes Superior...
- Orientation Tuning of Correlated Activity in the D...
- This Week in The Journal
- HuD and the Survival Motor Neuron Protein Interact...
-
▼
Νοε 29
(187)
- ► Σεπτεμβρίου (6470)
-
►
2016
(4179)
- ► Σεπτεμβρίου (638)
- ► Φεβρουαρίου (526)
- ► Ιανουαρίου (517)
Τετάρτη 29 Νοεμβρίου 2017
PPAR{delta} elicits ligand-independent repression of Trefoil Factor Family to limit prostate cancer growth
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου