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Τετάρτη 29 Νοεμβρίου 2017

The assessment of neurovascular coupling with the Addenbrooke's Cognitive Examination: a functional Transcranial Doppler Ultrasonographic Study

Cerebrovascular dysfunction occurs early in dementia and can be identified by Transcranial Doppler ultrasonography (TCD). Few studies have examined cerebral blood flow velocity (CBFv) responses to a detailed cognitive battery. This study aimed to characterise all CBFv responses, and the effect of hemispheric dominance, to the Addenbrooke's Cognitive Examination (ACE-III) in healthy volunteers. Forty volunteers underwent continuous bilateral TCD, beat-to-beat blood pressure (MAP) (Finapres), heart rate (HR) (electrocardiogram), and end-tidal CO2 (ETCO2) (capnography) monitoring. After 5 minutes baseline, all tasks from the ACE-III were performed in 3 sections (A: attention, fluency, memory, B: language, C: visuospatial, memory). Data are population mean normalised percentage (PM%) change from a twenty second baseline period prior to task initiation. Forty bilateral data sets were obtained (27 female, 37 right-hand dominant). All paradigms produced a sharp increase in CBFv in both dominant (PM% (range): 3.29 to 9.70%), and non-dominant (PM% (range): 4.34 to 11.63%), hemispheres at task initiation, with associated increases in (MAP) (PM% (range): 3.06 to 16.04%). ETCO2 did not differ significantly at task initiation (PM% (range): -1.1 to 2.4%, p>0.05). HR differed significantly across the A and C tasks at initiation (PM% (range): -1.1 to 2.4%, p<0.05), but not B tasks. In conclusion, all tasks resulted in increases in CBFv, differing significantly between paradigms. These results require further investigation in a cognitively impaired population.



from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2AnXfTh

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