Publication date: Available online 13 December 2017
Source:Clinical Neurophysiology
Author(s): Myung Sik Lee, Myung Jun Lee, Antonella Conte, Alfredo Berardelli
ObjectiveThe somatosensory temporal discrimination threshold (STDT), defined as the shortest time interval required for two tactile stimuli to be perceived as separate, is longer in patients with Parkinson's disease (PD). In this review, we discuss STDT findings in healthy subjects and in PD patients and the relationship between altered STDT and motor disturbances.MethodsA search was conducted on PubMed for papers dealing with PD and temporal discrimination published from January 1990 to July 2017.ResultsAbnormal STDT in PD correlates with disease duration, disease severity and degree of nigrostriatal dopamine loss, and responds to dopaminergic medication. In PD, a prolonged STDT does not correlate, or only marginally correlates, with clinically assessed bradykinesia of finger tapping. By contrast, a prolonged STDT correlates with the variability in amplitude and speed of finger tapping as assessed by means of neurophysiological techniques and may contribute to impaired finger dexterity in PD.ConclusionsWe suggest that abnormal temporal processing of sensory information in PD generates incorrect signals for the execution and control of voluntary movements.SignificanceThis review sheds light on unsolved questions regarding the relationship between STDT alterations and motor disturbances in PD and proposes directions for future research on this topic.
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2iYBtLE
Αρχειοθήκη ιστολογίου
-
►
2023
(269)
- ► Φεβρουαρίου (133)
- ► Ιανουαρίου (136)
-
►
2022
(2046)
- ► Δεκεμβρίου (165)
- ► Σεπτεμβρίου (161)
- ► Φεβρουαρίου (165)
-
►
2021
(3028)
- ► Δεκεμβρίου (135)
- ► Σεπτεμβρίου (182)
- ► Φεβρουαρίου (324)
-
►
2020
(1051)
- ► Δεκεμβρίου (292)
- ► Σεπτεμβρίου (60)
- ► Φεβρουαρίου (28)
-
►
2019
(2277)
- ► Δεκεμβρίου (18)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (89)
-
►
2018
(26280)
- ► Δεκεμβρίου (189)
- ► Φεβρουαρίου (6130)
- ► Ιανουαρίου (7050)
-
▼
2017
(33948)
-
▼
Δεκεμβρίου
(6715)
-
▼
Δεκ 13
(435)
- High PD-L1 expression indicates poor prognosis of ...
- Intraoperative Techniques for the Plastic Surgeon ...
- Pemetrexed-induced painful erythematous nodules in...
- Reliable new measures capturing low-frequency fluc...
- Hereditary and familial thyroid tumours
- Issue Information
- Special types of thyroid carcinoma
- Molecular alterations of neuroendocrine tumours of...
- Heritable forms of primary hyperparathyroidism: a ...
- A user's guide to non-invasive follicular thyroid ...
- Succinate dehydrogenase (SDH)-deficient neoplasia
- What's new in pituitary pathology?
- Annual review issue
- Gastroenteropancreatic neuroendocrine neoplasms: s...
- Annual review issue: An overview of 50 years of pr...
- Molecular pathology of thyroid tumours of follicul...
- Well-differentiated pancreatic neuroendocrine tumo...
- Pathology and genetics of phaeochromocytoma and pa...
- Challenges in surgical pathology of adrenocortical...
- A comprehensive management protocol to treat cleft...
- Stiffness and strength of cranioplastic implant sy...
- Commentary: “Maxillofacial growth and speech outco...
- Comparative Study of Biomechanical Stability Of Re...
- Predictors of speech outcomes in children with Pie...
- Hemoglobin, C-reactive protein and ferritin in pat...
- The forgotten organ
- A comprehensive management protocol to treat cleft...
- Stiffness and strength of cranioplastic implant sy...
- Commentary: “Maxillofacial growth and speech outco...
- Comparative Study of Biomechanical Stability Of Re...
- Predictors of speech outcomes in children with Pie...
- Hemoglobin, C-reactive protein and ferritin in pat...
- Cutaneous Melanocytoma With CRTC1-TRIM11 Fusion: R...
- The Morphologic Spectrum of Sertoliform Cystadenom...
- Site-specific Differences in Colonic Adenocarcinom...
- Prognostic Significance of Periadnexal Extension i...
- Dermatofibrosarcoma Protuberans of Distal Extremit...
- Acquired myospherulosis secondary to gluteal augme...
- Antibiotic Prophylaxis After Immediate Breast Reco...
- Absorbable Antibiotic Beads Prophylaxis in Immedia...
- Indocyanine Green Angiography Use in Breast Recons...
- Low Dose Insulin as an Anti-Scarring Therapy in Br...
- The “Boomerang Lift”: A 3-Step Compartment Based A...
- MRI screening of the internal auditory canal: Is g...
- Combined use of a nanocarbon suspension and 99mTc-...
- Corrigendum to “A European randomised controlled t...
- Reinforcement of Single Implant-Retained Mandibula...
- Optical and Mechanical Properties of Newly Develop...
- Effect of Implant Connection Type and Depth on the...
- Impact of Anxiety on the Satisfaction of Dental Im...
- Skin tissue engineering using 3D bioprinting – an ...
- Determination of reference values for normal crani...
- The role of angiogenesis, inflammation and estroge...
- Smoking as a risk factor for Panniculectomy: An an...
- “Long-term craniofacial morphology in young adults...
- Distribution of the internal nasal branch of the i...
- Microinvasive parathyroidectomy: Incremental impro...
- Nanoparticle delivery of RNA-based therapeutics to...
- An innovative solution for T-tube obstruction: The...
- Clinical implications of magnetic resonance imagin...
- Brain volume changes in hyposmic patients before a...
- Use of autologous adipose-derived mesenchymal stem...
- When should a level IIB neck dissection be perform...
- Effect of rural and urban geography on larynx canc...
- Lifelong behavioral and neuropathological conseque...
- Predictors of post-stroke body temperature elevation
- Isolated and repeated stroke-like episodes in a mi...
- Voice Range Change After Injection Laryngoplasty f...
- Voice Range Change After Injection Laryngoplasty f...
- Editorial overview: Glial biology
- Contents page
- Editorial Board
- Radium-223 international early access program: res...
- Validation of the eighth clinical American Joint C...
- Pacritinib and its use in the treatment of patient...
- First-decade patient with colorectal cancer carryi...
- Is inpatient ictal video-electroencephalographic m...
- Preclinical evaluation of SCC244 (Glumetinib), a n...
- Afatinib is a new therapeutic approach in chordoma...
- Molecularly Targeted Cancer Combination Therapy wi...
- Inhibiting Nuclear Phospho-Progesterone Receptor E...
- Anti-Tumor Activity of Entrectinib, a Pan-TRK, ROS...
- Phase 1 dose-escalation study of anti CTLA-4 antib...
- Use of PRO measures to inform tolerability in onco...
- Clinical and Genetic Implications of DNA Mismatch ...
- Linc-ROR promotes esophageal squamous cell carcino...
- Adipocytes promote cholangiocarcinoma metastasis t...
- Choroidal metastases as the presenting feature of ...
- Diagnosis and management of gastrointestinal strom...
- Expression of WW domain-containing protein 2 is co...
- Occupational doses of cardiologists in cath labs a...
- Extramedullary sarcomatoid variant of plasmablasti...
- Optical diagnostics in oral cancer: An update on R...
- Intrarectal fixative for positioning of the prosta...
- Cancer-related fatigue treatment: An overview
- Neurofibromatosis type-1 in a patient with ataxia-...
- Quantitative determination of tumor platinum conce...
- Agreement analysis between three different short g...
- Assessment of the scatter correction procedures in...
- Accelerated hypofractionation (OCTA SHOT): Palliat...
-
▼
Δεκ 13
(435)
- ► Σεπτεμβρίου (6470)
-
▼
Δεκεμβρίου
(6715)
-
►
2016
(4179)
- ► Σεπτεμβρίου (638)
- ► Φεβρουαρίου (526)
- ► Ιανουαρίου (517)
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου