Case series: Slowing alpha rhythm in late-stage ALS patients

Publication date: February 2018
Source:Clinical Neurophysiology, Volume 129, Issue 2
Author(s): Matthias R. Hohmann, Tatiana Fomina, Vinay Jayaram, Theresa Emde, Jennifer Just, Matthis Synofzik, Bernhard Schölkopf, Ludger Schöls, Moritz Grosse-Wentrup
The alpha peak frequency (APF) of the human electroencephalogram (EEG) is a reliable neurophysiological marker for cognitive abilities. In these case series, we document a shift of the APF towards the lower end of the EEG spectrum in two completely locked-in ALS patients. In not completely locked-in ALS patients, the alpha rhythm lies within the common frequency range. We discuss potential implications of this shift for the largely unknown cognitive state of completely locked-in ALS patients.



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