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Σάββατο 6 Ιανουαρίου 2018

Primary Intracranial Leiomyosarcoma in an Immunocompetent Patient: Case Report and Review of the Literature

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Publication date: Available online 6 January 2018
Source:Clinical Neurology and Neurosurgery
Author(s): Shannon J. Gallagher, Stephen A. Rosenberg, David Francis, Shahriar Salamat, Steven P. Howard, Randall J. Kimple
Primary leiomyosarcoma is a rare tumor in the CNS, with few reported cases. Here, we describe a case of a primary intracranial leiomyosarcoma of the tentorium cerebelli. A 43-year-old woman presented with headache, acute vision loss, and difficulty speaking. MRI revealed a large heterogeneous-enhancing occipital mass, which was subsequently resected and diagnosed as a primary intracranial leiomyosarcoma. The patient went onto adjuvant radiotherapy delivering 60 Gy in 30 fractions. These tumors are exceedingly rare in immunocompetent individuals. We reviewed the 16 cases that have been reported in the literature. Surgical resection was the most common treatment (92%) with 53% receiving adjuvant radiation. There currently is no standard treatment regimen for intracranial leiomyosarcomas. Additional case reports that include descriptive treatment approaches with patient outcomes may help ascertain the best approach to treating these malignancies.



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