Respiratory-related leg movements are associated with serotonergic antidepressants but not bupropion

Introduction: Respiratory-related leg movements (RRLMs) are contractions of the anterior tibialis occurring at the termination of respiratory events. Respiratory events terminating with such a leg movement produce larger heart rate increases than events without a leg movement, suggesting that RRLMs may potentially be a marker for the increased cardiovascular risk associated with obstructive sleep apnea (OSA). Selective serotonin reuptake inhibitors (SSRIs) and venlafaxine, but not bupropion, increase the risk for periodic limb movements of sleep (PLMS).

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