Rectal EMR for enteric ganglia: Is deeper better?

Hirschsprung's disease (HD) is characterized by the aberrant arrest of caudad migration of neural crest cells, resulting in the absence of ganglion cells within the submucosal and myenteric plexuses of the distal colorectum. The aganglionic segment extends proximally from the anorectum up to varying lengths of the colon. The loss of ganglion cells leads to a loss of peristalsis and neurotransmitter release, particularly nitric oxide and vasoactive intestinal peptide, causing a functional colonic obstruction.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2ob79iW