Detection of Cytomegalovirus in Colonic Mucosa of Children With Inflammatory Bowel Disease

The aim of this study was to determine the frequency and management of cytomegalovirus (CMV) detection in colonic mucosa of children with inflammatory bowel disease (IBD). Children with moderate-to-severe colitis who had sigmoid biopsy specimens evaluated for CMV by hematoxylin and eosin (H&E) staining, immunohistochemistry (IHC), and polymerase chain reaction (PCR) were included. A total of 90 sigmoid biopsies were collected from 67 patient encounters from 58 patients with colitis including biopsy samples from colectomy specimens of 8 patients who had colectomy during the study period. Four of 61 patient encounters (6.6%) with ulcerative colitis/IBD-unclassified, 2 with corticosteroid refractory disease, had positive biopsies for CMV by PCR but negative H&E and IHC. They responded to escalated medical therapy, without needing anti-viral therapy or colectomy over a median duration of follow-up of 1.1 year. CMV presence is uncommon in colonic mucosa of children with inflammatory bowel disease. Address correspondence and reprint requests to Wael El-Matary, MD, MSc, FRCPCH, FRCPC, Associate Professor and Section Head, Section of Pediatric Gastroenterology, Departments of Pediatrics, Faculty of Medicine, University of Manitoba AE 408, Health Sciences Centre, 840 Sherbrook St., Winnipeg, Manitoba R3A 1S1, Canada (e-mail: welmatary@hsc.mb.ca). Received 3 September, 2017 Accepted 27 February, 2018 Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal's Web site (www.jpgn.org). Source of funding: W.E.-M. is supported with a grant from the University of Manitoba and the Children's Hospital Research Institute of Manitoba. The authors report no conflicts of interest. © 2018 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,

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