Effective post-operative analgesia using intravenous flurbiprofen and acetaminophen.

Publication date: Available online 28 March 2018
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Mitsuhiro Yoshida, Yoshitaka Shimizu, Keita Yoshida, Akari Mukai, Mitsuru Doi, Masahiro Irifune
PurposeManagement of postoperative pain is one of the most important components in postoperative care, because most patients suffer from pain after dental surgery. The aim of this study was to evaluate whether acetaminophen can be an alternative to fentanyl in combination with a nonsteroidal anti-inflammatory drug (NSAID) as an analgesic after dental surgery, in cases where narcotic drugs are contraindicated.MethodsThe subjects were 24- to 54-year-old male patients who underwent enucleation of a mandibular cyst under general anesthesia. We measured time from discontinuation of anesthetic administration until discharge from the operating room and postoperative pain during four hours after discharge. We compared the above parameters between patients who were intravenously administered an NSAID such as flurbiprofen with fentanyl (NSAID/fentanyl group) and those administered an NSAID with acetaminophen (NSAID/acetaminophen group). Parametric data of time were analyzed using Student's t-test. Non-parametric data of the analgesic effect were analyzed using Mann–Whitney U-test.ResultsTime until discharge from the operating room after discontinuation of anesthetics in the NSAID/fentanyl group was significantly longer than that in the NSAID/acetaminophen group (P < 0.05). In contrast, there was no significant difference in analgesic effect between the NSAID/acetaminophen and NSAID/fentanyl groups (P > 0.05).ConclusionAlthough the recovery time in the operating room of flurbiprofen and acetaminophen administered group was significantly shorter than that of flurbiprofen and fentanyl group, the postoperative analgesic effects of both drugs were equipotent. Therefore, acetaminophen can be an alternative to fentanyl in cases where narcotic drugs are contraindicated.



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