Oral lichen sclerosus- a review of clinical presentation, treatment, and clinical outcomes

Publication date: Available online 3 August 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Stephanie L. Bevans, Jordan M. Keeley, Naveed Sami
ObjectiveTo evaluate disease involvement, treatment and response, and malignant potential of oral LS.Study DesignWe conducted a review of the literature of 37 cases of oral LS. We looked specifically for the following data: patient demographics, disease involvement, treatment, treatment response, follow-up duration, symptoms, risk factors for oral malignancy, and malignant transformation.ResultsThe most common area of oral involvement included the labial mucosa (67.6%). 38.5% with oral involvement reported symptoms, and 35.1% exhibited extra-oral manifestations. Patients were less likely to receive treatment if asymptomatic (62.5%) than if symptomatic (80%). Topical steroids were more efficacious (66.7%) compared to other treatments. 25.0% of patients were found to have risk factors for malignancy. No patients had malignant transformation of oral lesions at follow-up (mean follow-up 22.1 months; median 12 months).ConclusionMore data and longer follow-up is required to determine the long-term clinical outcomes of oral LS.



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