ATF6α regulates airway hyperreactivity, smooth muscle proliferation, and contractility

Publication date: Available online 27 September 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Hirotoshi Unno, Marina Miller, Peter Rosenthal, Andrew Beppu, Sudipta Das, David H. Broide

Teaser

ORMDL3 on chromosome 17q21 is highly linked to asthma and regulates several downstream pathways including ATF6α. We demonstrated that ATF6α in airway smooth muscle (ASM) plays an important role in ASM contractility, proliferation, and AHR.


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