Breaks in Sitting Time: Effects on Continuously Monitored Glucose and Blood Pressure

Purpose: We examined the effects of interrupting prolonged sitting with multiple 2-min walking breaks or one 30-min continuous walking session on glucose control and ambulatory blood pressure (ABP). Methods: Ten overweight/obese, physically inactive participants (five men; 32 ± 5 yr; BMI, 30.3 ± 4.6 kg·m−2) participated in this randomized four-trial crossover study, with each trial performed on a separate, simulated workday lasting 9 h: 1) 30 min of continuous moderate-intensity (30-min MOD) walking at 71% ± 4% HRmax; 2) 21 × 2 min bouts of moderate-intensity (2-min MOD) walking at 53% ± 5% HRmax, each performed every 20 min (42 min total); 3) 8 × 2 min bouts of vigorous-intensity (2-min VIG) walking at 79% ± 4% HRmax, each performed every hour (16 min total); 4) 9 h of prolonged sitting (SIT). Participants underwent continuous interstitial glucose monitoring and ABP monitoring during and after the simulated workday spent in the laboratory, with primary data analysis from 12:30 h to 07:00 h the next morning. Results: Compared with SIT (5.6 ± 1.1 mmol·L−1), mean 18.7-h glucose was lower during the 2-min MOD (5.2 ± 1.1 mmol·L−1) and 2-min VIG (5.4 ± 0.9 mmol·L−1) trials and mean 18.7-h glucose during the 30-min MOD trial (5.1 ± 0.8 mmol·L−1) was lower than all other trials (P

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