“Effects of Leukocyte- and Platelet-rich Fibrin alone and Combined with Hyaluronic Acid on Pain, Oedema, and Trismus after Surgical Extraction of Impacted Mandibular Third Molars”

Publication date: Available online 13 December 2017
Source:Journal of Oral and Maxillofacial Surgery
Author(s): İbrahim Murat Afat, Emine Tuna Akdoğan, Onur Gönül
PurposeIn this prospective randomised double-blind controlled study, we evaluated the effects of leukocyte- and platelet-rich fibrin (L-PRF) alone and combined with hyaluronic acid (HA) sponge on pain, oedema, and trismus after mandibular third molar (M3) surgery.MethodsIn total, 60 patients were included in this study. The patients were randomly divided into 3 groups: Group L-PRF (L-PRF was applied to the socket), Group L-PRF+HA (L-PRF+HA was applied to the socket), Group Control (nothing was applied). The primary outcome variables were oedema (tragus to pogonion (TPO), tragus to labial commissure (TCO), angulus mandibula to lateral canthus (ACA)), trismus on post-operative days 2 and 7, and visual analogue scale (VAS) post-operative pain scores from hour 6 to day 7.ResultsThe results after extraction on TPO values were significantly higher in Control Group both on day 2 (higher than Group L-PRF+HA) and on day 7 (higher than both Groups). The mean increase in TCO on day 2 was significantly higher in the control group than in the L-PRF+HA group. The mean increase in ACA at days 2 and 7 was significantly higher in the control group than in the L-PRF and L-PRF+HA groups. There was no significant difference among groups in trismus and visual analogue scale (VAS) pain scores. Analgesic intake on surgery day in the L-PRF+HA group was significantly lower.ConclusionOur results imply that L-PRF, particularly when combined with HA, can be used to minimise post-operative oedema after M3 surgery. However, further studies with larger samples are required.



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