[Bradykinin-induced angioedema : Definition, pathogenesis, clinical presentation, diagnosis and therapy].

[Bradykinin-induced angioedema : Definition, pathogenesis, clinical presentation, diagnosis and therapy].

HNO. 2015 Nov 23;

Authors: Hahn J, Bas M, Hoffmann TK, Greve J

Abstract
The incidence of bradykinin-induced angioedema is considerably lower than that of histamine-induced forms; however, the same is true for the clinician's knowledge of this condition. Bradykinin-induced angioedemas include hereditary angioedema (HAE), as well as acquired forms induced by drugs or antibody formation, e.g., during the course of oncologic disease. Drug-induced forms affect almost exclusively the head and neck region, and are thus important for the otorhinolaryngologist. Clear differentiation between histamine-induced angioedema (e. g., connected to allergy/urticaria) and bradykinin-induced angioedema is essential for selection of the specific treatment and may be lifesaving. Antihistamines and cortisone derivatives have no relevant effect in bradykinin induced-angioedema, whereas blood-derived C1 esterase inhibitor and bradykinin receptor 2 antagonists represent effective therapeutic options-both for acute and prophylactic treatment.

PMID: 26597136 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1MD3JLX
via IFTTT